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Adamina Vocero-Akbani
Researcher at Washington University in St. Louis
Publications - 5
Citations - 3895
Adamina Vocero-Akbani is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Fusion protein & Transduction (genetics). The author has an hindex of 5, co-authored 5 publications receiving 3801 citations. Previous affiliations of Adamina Vocero-Akbani include Howard Hughes Medical Institute.
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Journal ArticleDOI
In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse
TL;DR: It is shown that intraperitoneal injection of the 120-kilodalton beta-galactosidase protein, fused to the protein transduction domain from the human immunodeficiency virus TAT protein, results in delivery of the biologically active fusion protein to all tissues in mice, including the brain.
Journal ArticleDOI
Transduction of full-length TAT fusion proteins into mammalian cells:TAT-p27Kip1 induces cell migration
Hikaru Nagahara,Adamina Vocero-Akbani,Eric L. Snyder,Alan L. Ho,Dawn G. Latham,Natalie A. Lissy,Michelle Becker-Hapak,Sergei A. Ezhevsky,Steven F. Dowdy +8 more
TL;DR: Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27 Kip1 induces cell migration and promotes cell migration in mice.
Journal ArticleDOI
Transforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity
Hikaru Nagahara,Sergei A. Ezhevsky,Adamina Vocero-Akbani,Philipp Kaldis,Mark J. Solomon,Steven F. Dowdy +5 more
TL;DR: Observations demonstrate that TGF-beta signaling mediates a G(1) arrest in HepG2 cells by targeting Cdk2 CAK and suggests the presence of at least two mammalian CAKs: one specific for Ctk2 and one for Cdk4/6.
Book ChapterDOI
Transduction of full-length Tat fusion proteins directly into mammalian cells: analysis of T cell receptor activation-induced cell death.
TL;DR: It is concluded that the methodology generates highly efficient transducible proteins that are biologically active and have broad potential in the manipulation of biological experimental systems, such as apoptotic induction, cell cycle progression, and differentiation, and in the delivery of pharmacologically relevant proteins.
Book ChapterDOI
Protein transduction: delivery of Tat-GTPase fusion proteins into mammalian cells.
TL;DR: Transduction of full-length Tat fusion proteins directly into ∼100% of primary or transformed cells has broad implications for manipulating intracellular processes in both experimental in vitro tissue culture systems and animal models.