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Alan L. Ho
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 124
Citations - 13892
Alan L. Ho is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 40, co-authored 99 publications receiving 10668 citations. Previous affiliations of Alan L. Ho include Cornell University & Washington University in St. Louis.
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Journal ArticleDOI
In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse
TL;DR: It is shown that intraperitoneal injection of the 120-kilodalton beta-galactosidase protein, fused to the protein transduction domain from the human immunodeficiency virus TAT protein, results in delivery of the biologically active fusion protein to all tissues in mice, including the brain.
Journal ArticleDOI
Tumor mutational load predicts survival after immunotherapy across multiple cancer types.
Robert M. Samstein,Chung-Han Lee,Chung-Han Lee,Alexander N. Shoushtari,Alexander N. Shoushtari,Matthew D. Hellmann,Matthew D. Hellmann,Ronglai Shen,Yelena Y. Janjigian,Yelena Y. Janjigian,David Barron,Ahmet Zehir,Emmet Jordan,Antonio Omuro,Thomas Kaley,Sviatoslav M. Kendall,Robert J. Motzer,Robert J. Motzer,A. Ari Hakimi,Martin H. Voss,Martin H. Voss,Paul Russo,Jonathan E. Rosenberg,Jonathan E. Rosenberg,Gopa Iyer,Gopa Iyer,Bernard H. Bochner,Dean F. Bajorin,Dean F. Bajorin,Hikmat Al-Ahmadie,Jamie E. Chaft,Jamie E. Chaft,Charles M. Rudin,Charles M. Rudin,Gregory J. Riely,Gregory J. Riely,Shrujal S. Baxi,Shrujal S. Baxi,Alan L. Ho,Alan L. Ho,Richard J. Wong,David G. Pfister,David G. Pfister,Jedd D. Wolchok,Jedd D. Wolchok,Christopher A. Barker,Philip H. Gutin,Cameron Brennan,Viviane Tabar,Ingo K. Mellinghoff,Lisa M. DeAngelis,Charlotte E. Ariyan,Nancy Y. Lee,William D. Tap,William D. Tap,Mrinal M. Gounder,Mrinal M. Gounder,Sandra P. D'Angelo,Sandra P. D'Angelo,Leonard B. Saltz,Leonard B. Saltz,Zsofia K. Stadler,Zsofia K. Stadler,Howard I. Scher,Howard I. Scher,José Baselga,José Baselga,Pedram Razavi,Pedram Razavi,Christopher A. Klebanoff,Christopher A. Klebanoff,Rona Yaeger,Rona Yaeger,Neil H. Segal,Neil H. Segal,Geoffrey Y. Ku,Geoffrey Y. Ku,Ronald P. DeMatteo,Marc Ladanyi,Naiyer A. Rizvi,Michael F. Berger,Nadeem Riaz,David B. Solit,Timothy A. Chan,Luc G. T. Morris +84 more
TL;DR: Analysis of advanced cancer patients treated with immune-checkpoint inhibitors shows that tumor mutational burden, as assessed by targeted next-generation sequencing, predicts survival after immunotherapy across multiple cancer types.
Journal ArticleDOI
Transduction of full-length TAT fusion proteins into mammalian cells:TAT-p27Kip1 induces cell migration
Hikaru Nagahara,Adamina Vocero-Akbani,Eric L. Snyder,Alan L. Ho,Dawn G. Latham,Natalie A. Lissy,Michelle Becker-Hapak,Sergei A. Ezhevsky,Steven F. Dowdy +8 more
TL;DR: Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27 Kip1 induces cell migration and promotes cell migration in mice.
Journal ArticleDOI
Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer
Alan L. Ho,Ravinder K. Grewal,Rebecca Leboeuf,Eric J. Sherman,David G. Pfister,Désirée Deandreis,Keith S. Pentlow,Pat Zanzonico,Sofia Haque,Somali Gavane,Ronald Ghossein,Julio C. Ricarte-Filho,José Carlos de Miguel Domínguez,Ronglai Shen,R. Michael Tuttle,Steve Larson,James A. Fagin +16 more
TL;DR: Selumetinib produces clinically meaningful increases in iodine uptake and retention in a subgroup of patients with thyroid cancer that is refractory to radioiodine; the effectiveness may be greater in patients with RAS-mutant disease.
Journal ArticleDOI
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.
Jordi Barretina,Barry S. Taylor,Barry S. Taylor,Shantanu Banerji,Shantanu Banerji,Alexis Ramos,Alexis Ramos,Mariana Lagos-Quintana,Penelope DeCarolis,Kinjal Shah,Kinjal Shah,Nicholas D. Socci,Barbara A. Weir,Barbara A. Weir,Alan L. Ho,Derek Y. Chiang,Derek Y. Chiang,Boris Reva,Craig H. Mermel,Craig H. Mermel,Gad Getz,Yevgeniy Antipin,Rameen Beroukhim,Rameen Beroukhim,John E. Major,Charlie Hatton,Richard Nicoletti,Megan Hanna,Ted Sharpe,Timothy Fennell,Kristian Cibulskis,Robert C. Onofrio,Tsuyoshi Saito,Neerav Shukla,Christopher Lau,Sven Nelander,Serena J. Silver,Carrie Sougnez,Agnes Viale,Wendy Winckler,Wendy Winckler,Robert G. Maki,Levi A. Garraway,Levi A. Garraway,Alex E. Lash,Heidi Greulich,Heidi Greulich,David E. Root,William R. Sellers,Gary K. Schwartz,Cristina R. Antonescu,Eric S. Lander,Harold E. Varmus,Marc Ladanyi,Chris Sander,Matthew Meyerson,Samuel Singer +56 more
TL;DR: An integrative analysis of DNA sequence, copy number and mRNA expression in 207 samples encompassing seven major subtypes of soft-tissue sarcomas yields a detailed map of molecular alterations across diverse sarcoma subtypes and suggests potential subtype-specific targets for therapy.