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Adnan T. Bhutta

Researcher at University of Arkansas for Medical Sciences

Publications -  72
Citations -  5444

Adnan T. Bhutta is an academic researcher from University of Arkansas for Medical Sciences. The author has contributed to research in topics: Extracorporeal membrane oxygenation & Medicine. The author has an hindex of 26, co-authored 60 publications receiving 4967 citations. Previous affiliations of Adnan T. Bhutta include University of Arkansas Medical Center & University of Pennsylvania.

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Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis.

TL;DR: Children who were born preterm are at risk for reduced cognitive test scores and their immaturity at birth is directly proportional to the mean cognitive scores at school age.
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Vulnerability of the developing brain. Neuronal mechanisms.

TL;DR: The authors propose two primary mechanisms leading to enhanced neuronal cell death in the immature brain: NMDA-mediated excitotoxicity resulting from repetitive or prolonged pain and enhanced naturally occurring neuronal apoptosis during early development due to multiple metabolic stresses or lack of social stimulation.
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Ketamine reduces the cell death following inflammatory pain in newborn rat brain.

TL;DR: Repetitive neonatal pain accentuates neuronal excitation and cell death in developmentally regulated cortical and subcortical areas, which decreases the acquisition of visual-spatial clues, short-term and long-term memory, and increases pain latencies, and Ketamine analgesia mitigates most of these effects.