Advances in dearomatization strategies of indoles

Formation of five- and six-membered heterocyclic rings under radical cyclisation conditions

The field of “molecular machines” based on interlocking ring compounds started about twenty years ago with the deliberate synthesis of molecules or molecular assemblies which could be set in motion...

Molecular Muscles: From Species in Solution to Materials and Devices

Copper(II) carboxylate-promoted intramolecular carboamination of alkenes for the synthesis of polycyclic lactams.

A copper sulfate pentahydrate-catalyzed intramolecular Friedel–Crafts reaction using an oxocarbenium species derived from a furan ring as the alkylating agent was developed for the first time. By using this protocol, spirofurooxindoles 9 with multi-reactive sites were synthesized simply and concisely. In addition, selective hydrogenation of the endo-cyclic double bond and full hydrogenation of the endo and exo-cyclic double bonds of spirofurooxindoles 9 provided spirofurooxindoles 11 and 12, respectively.

Afua S. Kyei

Papers

Radical dearomatising spirocyclisations onto the C-2 position of benzofuran and indole