R
Robert M. Adlington
Researcher at University of Oxford
Publications - 252
Citations - 4205
Robert M. Adlington is an academic researcher from University of Oxford. The author has contributed to research in topics: Isopenicillin N synthase & Tripeptide. The author has an hindex of 33, co-authored 252 publications receiving 4037 citations. Previous affiliations of Robert M. Adlington include Ghent University & Eli Lilly and Company.
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Journal ArticleDOI
The reaction cycle of isopenicillin N synthase observed by X-ray diffraction
Nicolai I. Burzlaff,Peter J. Rutledge,Ian J. Clifton,Charles M. H. Hensgens,Michael Pickford,Robert M. Adlington,Peter L. Roach,Jack E. Baldwin +7 more
TL;DR: These mono- and bicyclic structures support the hypothesis of a two-stage reaction sequence leading to penicillin, as the formation of a monocyclic sulphoxide product from ACmC is most simply explained by the interception of a high-valency iron-oxo species.
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Recent applications of the Shapiro reaction
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Purification of isopenicillin N synthetase.
C P Pang,Bulbul Chakravarti,Robert M. Adlington,Hong-Hoi Ting,Robert L. White,G S Jayatilake,Jack E. Baldwin,Edward P. Abraham +7 more
TL;DR: Preliminary experiments have shown that a similar isopenicillin N synthetase can be extracted from Streptomyces clavuligerus and resemble each other closely in their Mr, in their mobility on electrophoresis in polyacrylamide gel and in their requirement for Fe2+ and ascorbate for maximum activity.
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A short biomimetic synthesis of the meroterpenoids guajadial and psidial A.
Andy Lawrence,Robert M. Adlington,Jack E. Baldwin,Victor Lee,Jessica A. Kershaw,Amber L. Thompson +5 more
TL;DR: The biosynthesis of the meroterpenoid guajadial was previously hypothesized to occur via a hetero-Diels-Alder reaction between caryophyllene and an o-quinone methide, but this hypothesis has been verified via the biomimetic synthesis of gujadial and psidial A in an aqueous three-component coupling reaction.
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Enantiospecific, Biosynthetically Inspired Formal Total Synthesis of (+)-Liphagal
TL;DR: A biosynthetically inspired synthesis of (+)-liphagal has been achieved from (+)-sclareolide in 13 steps (9% overall yield) using a biomimetic ring expansion of a highly stabilized benzylic carbocation.