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Ag Uren
Researcher at Genentech
Publications - 1
Citations - 1003
Ag Uren is an academic researcher from Genentech. The author has contributed to research in topics: BCL10 & Zinc finger. The author has an hindex of 1, co-authored 1 publications receiving 977 citations.
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Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.
TL;DR: The human paracaspase prodomain binds Bcl10, a protein involved in the t(1;14)(p22;q32) translocation of mucosa-associated lymphoid tissue (MALT) lymphoma, and it is found that this fusion activates NF-kappaB and that the caspase domain is required for this function, since mutation of the conserved catalytic cysteine attenuates NF- kappaB activation.