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Agnieszka Kaczmarczyk
Researcher at National University of Ireland, Galway
Publications - 5
Citations - 128
Agnieszka Kaczmarczyk is an academic researcher from National University of Ireland, Galway. The author has contributed to research in topics: Kinetochore & Aurora B kinase. The author has an hindex of 4, co-authored 4 publications receiving 113 citations.
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Journal ArticleDOI
Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state.
Lisa Prendergast,Chelly van Vuuren,Agnieszka Kaczmarczyk,Volker Doering,Daniela Hellwig,Nadine Quinn,Christian Hoischen,Stephan Diekmann,Kevin F. Sullivan +8 more
TL;DR: It is proposed that the CENP-A and H3-CenP-T/W nucleosome components of the centromere are specialized for centromeric and kinetochore activities, respectively.
Journal ArticleDOI
Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint.
Aisling O'Connor,Stefano Maffini,Michael D. Rainey,Agnieszka Kaczmarczyk,David C. A. Gaboriau,Andrea Musacchio,Corrado Santocanale +6 more
TL;DR: Using small molecule kinase inhibitors, PLK1 and Aurora B cooperate to avoid mitotic slippage upon microtubule depolymerization and to promote their reciprocal recruitment at kinetochores.
Book ChapterDOI
Centromeres: assembling and propagating epigenetic function
TL;DR: The assembly of CENP-A chromatin following DNA replication and the re-establishment of this network of constitutive proteins have emerged as critical mechanisms for understanding how the centromere is replicated during the cell cycle.
Journal ArticleDOI
CENP-W plays a role in maintaining bipolar spindle structure.
TL;DR: It is proposed that CENP-W, by influencing proper kinetochore assembly, particularly microtubule docking sites, can confer spindle pole resistance to traction forces exerted by motor proteins during chromosome congression.
Journal ArticleDOI
BLM helicase overexpressed in human gliomas contributes to diverse responses of human glioma cells to chemotherapy
TL;DR: In this article , the effects of chemotherapeutics on cell proliferation, DNA damage and apoptosis were determined with flow cytometry, immunofluorescence, Western blotting and RNA sequencing.