Agnieszka Waclawik

TL;DR: Pregnancy establishment in pigs requires the biphasic pattern of oestrogen secretion by conceptuses on days 11-12 and 15-30 and higher PGE(2) secretion in uterine lumen coincides with the elevated expression of HOXA10 transcription factor critical for implantation.

TL;DR: A novel, dual role for PGF2α in corpora lutea is presented that depends on the acquisition of luteolytic sensitivity, based on the knowledge that P GF2α triggers pathways involved in lutelysis during the estrous cycle or/and may have an alternative function in maintaining progesterone synthesis during pregnancy.

TL;DR: The spatiotemporal expression of PG FS throughout the estrous cycle indicates an involvement of PGFS in regulating luteolysis in the pig and a supportive role of these enzymes in determining the increase of uterine PGE2/PGF2alpha ratio during maternal recognition of pregnancy is suggested.

TL;DR: In pigs, implantation and establishment of pregnancy is associated with upregulation of expression of proinflammatory factors, which include cytokines, growth factors, and lipid mediators, which probably activate inflammatory pathways in the endometrium.

TL;DR: The results suggest that E(2) prevents luteolysis through enzymatic modification of PG synthesis and that E (2), PGE(2), and endometrial PTGER2 are involved in a PGE (2) positive feedback loop in porcine endometrium.