A
Aikaterini Alexaki
Researcher at Drexel University
Publications - 10
Citations - 545
Aikaterini Alexaki is an academic researcher from Drexel University. The author has contributed to research in topics: Binding site & Long terminal repeat. The author has an hindex of 6, co-authored 10 publications receiving 513 citations.
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Journal ArticleDOI
Cellular Reservoirs of HIV-1 and their Role in Viral Persistence
TL;DR: Cell populations of the monocyte-macrophage lineage, which originate in the bone marrow, are of particular importance in HIV-1 persistence due to their ability to cross the blood-brain barrier and spread HIV- 1 infection in the immunoprivileged central nervous system (CNS).
Journal ArticleDOI
HIV-1 Infection of Bone Marrow Hematopoietic Progenitor Cells and Their Role in Trafficking and Viral Dissemination
Aikaterini Alexaki,Brian Wigdahl +1 more
TL;DR: Changes in the growth and differentiation process of HPCs may be involved in the generation of monocyte populations that are more susceptible and/or permissive to HIV-1, and have potentially altered trafficking profiles to several organs, including the CNS.
Journal ArticleDOI
Functional properties of the HIV-1 long terminal repeat containing single-nucleotide polymorphisms in Sp site III and CCAAT/enhancer binding protein site I.
Sonia Shah,Aikaterini Alexaki,Vanessa Pirrone,Satinder Dahiya,Michael R. Nonnemacher,Brian Wigdahl +5 more
TL;DR: The fact that they can still result in effective HIV-1 LTR-driven gene expression, particularly within the TF-1 cell line, has suggested that the low binding site affinities associated with the 3 T C/EBP site I and 5 T Sp site III are potentially compensated for by the interaction of nuclear factor-κB with its corresponding binding sites under selected physiological and cellular conditions.
Journal ArticleDOI
PMA-induced differentiation of a bone marrow progenitor cell line activates HIV-1 LTR-driven transcription.
Aikaterini Alexaki,Shane J. Quiterio,Yujie Liu,Bryan P. Irish,Evelyn Kilareski,Michael R. Nonnemacher,Brian Wigdahl +6 more
TL;DR: It is demonstrated that HIV-1 long terminal repeats (LTRs) from T-, M-, and dual-tropic molecular clones have similar basal LTR activity in TF-1 cells and that differentiation of these cells by PMA resulted in increased L TR activity.
Journal ArticleDOI
AP-1-directed human T cell leukemia virus type 1 viral gene expression during monocytic differentiation
Christian Grant,Christian Grant,Pooja Jain,Michael R. Nonnemacher,Katherine E. Flaig,Bryan P. Irish,Jaya Ahuja,Aikaterini Alexaki,Timothy Alefantis,Brian Wigdahl +9 more
TL;DR: Results have suggested that following infection of peripheral blood monocytes, HTLV‐1 viral gene expression may become up‐regulated by AP‐1 during differentiation into macrophages or dendritic cells.