P
Pooja Jain
Researcher at Drexel University
Publications - 89
Citations - 2219
Pooja Jain is an academic researcher from Drexel University. The author has contributed to research in topics: Immune system & Dendritic cell. The author has an hindex of 24, co-authored 82 publications receiving 1761 citations. Previous affiliations of Pooja Jain include Central Drug Research Institute.
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Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin.
TL;DR: This review focuses on the anti-inflammatory actions of flavonoids against chronic illnesses such as cancer, diabetes, cardiovascular diseases, and neuroinflammation with a special focus on apigenin, a relatively less toxic and non-mutagenic flavonoid with remarkable pharmacodynamics.
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Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein
Elizabeth Jaworski,Aarthi Narayanan,Rachel Van Duyne,Rachel Van Duyne,Shabana Shabbeer-Meyering,Sergey Iordanskiy,Sergey Iordanskiy,Mohammed Saifuddin,Ravi K. Das,Philippe V. Afonso,Gavin C. Sampey,Myung Chung,Anastas Popratiloff,Bindesh Shrestha,Mohit Sehgal,Pooja Jain,Akos Vertes,Renaud Mahieux,Fatah Kashanchi +18 more
TL;DR: Exosomes derived from infected cells found to contain Tax protein and proinflammatory mediators as well as viral mRNA transcripts, including Tax, HBZ, and Env, suggest that exosomes may play an important role in extracellular delivery of functional HTLV-1 proteins and mRNA to recipient cells.
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Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activation.
TL;DR: CNS recruitment of DCs correlates with disease severity in EAE via CCL2 chemotaxis and paracellular transmigration across the BBB, which is facilitated by ERK activation.
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DC-SIGN Mediates Cell-Free Infection and Transmission of Human T-Cell Lymphotropic Virus Type 1 by Dendritic Cells
TL;DR: It is suggested that DC-SIGN plays a critical role in HTLV-1 binding, transmission, and infection, thereby providing an attractive target for the development of antiretroviral therapeutics and microbicides.
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Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis.
TL;DR: This study shows that during EAE, especially immature DCs migrate into the CNS, where they may be crucial for the perpetuation of the CNS-targeted autoimmune response, and therapeutic targeting of α4 integrins affects DC trafficking intothe CNS and may therefore lead to the resolution ofThe CNS autoimmune inflammation by reducing the number of CNS professional APCs.