A
Ajda Coker-Gurkan
Researcher at Istanbul Kültür University
Publications - 36
Citations - 448
Ajda Coker-Gurkan is an academic researcher from Istanbul Kültür University. The author has contributed to research in topics: Apoptosis & PI3K/AKT/mTOR pathway. The author has an hindex of 11, co-authored 35 publications receiving 321 citations.
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Journal ArticleDOI
Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells
Yunus Akkoc,Özge Berrak,Elif Damla Arisan,Pinar Obakan,Ajda Coker-Gurkan,Narcin Palavan-Unsal +5 more
TL;DR: The hypothesis that blocking the PI3K/Akt pathway may further increasedCurcumin-induced apoptosis and overcome forced Bcl-2 expression level mediated autophagic responses against curcumin treatment in MCF-7 cells is supported.
Journal ArticleDOI
The inhibition of PI3K and NFκB promoted curcumin-induced cell cycle arrest at G2/M via altering polyamine metabolism in Bcl-2 overexpressing MCF-7 breast cancer cells
Özge Berrak,Yunus Akkoc,Elif Damla Arisan,Ajda Coker-Gurkan,Pınar Obakan-Yerlikaya,Narcin Palavan-Unsal +5 more
TL;DR: The results indicated that curcumin induced cell cycle arrest at G2/M phase by downregulation of cyclin B1 and Cdc2 and inhibited colony formation in MCF-7wt cells, but Bcl-2 overexpression prevented the inhibition of cell cycle associated proteins afterCurcumin treatment.
Journal ArticleDOI
CDK inhibitors induce mitochondria-mediated apoptosis through the activation of polyamine catabolic pathway in LNCaP, DU145 and PC3 prostate cancer cells.
Elif Damla Arisan,Pinar Obakan,Ajda Coker-Gurkan,Annarica Calcabrini,Enzo Agostinelli,Narcin Palavan Unsal +5 more
TL;DR: It is concluded that polyamine catabolism might have essential role in the cellular responses against CDK inhibitors in different androgen-responsive or irresponsive prostate cancer cells.
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Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells.
Ajda Coker-Gurkan,Derya Bulut,Recep Genc,Elif Damla Arisan,Pınar Obakan-Yerlikaya,Narcin Palavan-Unsal +5 more
TL;DR: Curcumin treatment for 48 h, prevented autocrine GH-triggered invasion-metastasis, EMT activation through inhibiting NF-κB signaling and miR-182-96-183 cluster expression and induced apoptotic cell death by modulating Bcl-2 family members in T47D breast cancer cells.
Journal ArticleDOI
Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells.
Ajda Coker-Gurkan,Merve Celik,Merve Ugur,Elif Damla Arisan,Pınar Obakan-Yerlikaya,Zeynep Begum Durdu,Narcin Palavan-Unsal +6 more
TL;DR: Curcumin could overcome the GH-mediated resistant phenotype via modulating cell survival, death-related signaling routes and activating PA catabolic pathway through focusing on NF-κB signaling and polyamine metabolism in autocrine GH-expressing MCF-7, MDA-MB-453 and MDA -MB-231 breast cancer cells.