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Akanksha Bansal
Researcher at University of Ulm
Publications - 3
Citations - 90
Akanksha Bansal is an academic researcher from University of Ulm. The author has contributed to research in topics: Fibril & Protein aggregation. The author has an hindex of 2, co-authored 3 publications receiving 37 citations.
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Journal ArticleDOI
Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis
Lynn Radamaker,Julian David Baur,Stefanie Huhn,Christian Haupt,Ute Hegenbart,Stefan Schönland,Akanksha Bansal,Matthias Schmidt,Marcus Fändrich +8 more
TL;DR: In this paper, the authors presented two ex vivo fibril structures of a λ3 LC-derived amyloid fibrils that were extracted from the explanted heart of a patient (FOR005).
Posted ContentDOI
Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis
Lynn Radamaker,Julian David Baur,Stefanie Huhn,Christian Haupt,Ute Hegenbart,Stefan Schönland,Akanksha Bansal,Matthias Schmidt,Marcus Fändrich +8 more
TL;DR: The first ex vivo fibril structures of a λ3 LC are presented, which imply that a 180° rotation around the disulfide bond and a major unfolding step are necessary for fibrils to form.
Journal ArticleDOI
AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils.
Akanksha Bansal,Matthias Schmidt,Matthies Rennegarbe,Christian Haupt,Falk Liberta,Sabrina Stecher,Ioana Puscalau-Girtu,Alexander Biedermann,Marcus Fändrich +8 more
TL;DR: In this article, the authors showed that ex vivo amyloid fibrils are more resistant to proteolysis than the in-vivo fibril proteins, and they also suggested that pathogenic AMIs may originate from proteolytic selection, allowing specific morphologies to proliferate and causing damage to the surrounding tissue.