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Akihiko Ikegami
Researcher at Case Western Reserve University
Publications - 11
Citations - 783
Akihiko Ikegami is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Fusobacterium nucleatum & Treponema denticola. The author has an hindex of 9, co-authored 11 publications receiving 670 citations. Previous affiliations of Akihiko Ikegami include State University of New York System.
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Journal ArticleDOI
Identification and Characterization of a Novel Adhesin Unique to Oral Fusobacteria
Yiping W. Han,Akihiko Ikegami,Chythanya Rajanna,Hameem I. Kawsar,Yun Zhou,Mei Li,Hakimuddin T. Sojar,Robert J. Genco,Howard K. Kuramitsu,Cheri X. Deng +9 more
TL;DR: A novelAdhesin, FadA (Fusobacterium adhesin A), was demonstrated to bind to the surface proteins of the oral mucosal KB cells and may be used as a marker to detect orally related fusobacteria.
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Transmission of an Uncultivated Bergeyella Strain from the Oral Cavity to Amniotic Fluid in a Case of Preterm Birth
Yiping W. Han,Akihiko Ikegami,Nabil F. Bissada,Melissa Herbst,Raymond W. Redline,Graham G. Ashmead,Graham G. Ashmead +6 more
TL;DR: Amniotic fluids of 34 pregnant women were examined by PCR and the Bergeyella strain identified in the patient's intrauterine infection originated from the oral cavity, suggesting the first direct evidence of oral-utero microbial transmission.
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Synergistic biofilm formation by Treponema denticola and Porphyromonas gingivalis.
TL;DR: In this study, in vitro biofilm formation by Treponema denticola and Porphyromonas gingivalis 381 displayed synergistic effects and the T. denticol flagella mutant as well as the cytoplasmic filament mutant were shown to be essential forBiofilm formation as wellAs coaggregation with P. gingivals.
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Multiple Functions of the Leucine-Rich Repeat Protein LrrA of Treponema denticola
TL;DR: The results suggest that the leucine-rich repeat protein LrrA plays a role in the attachment and penetration of human epithelial cells and coaggregation with Tannerella forsythensis and may play important roles in the virulence of T. denticola.
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Complementation of the fadA Mutation in Fusobacterium nucleatum Demonstrates that the Surface-Exposed Adhesin Promotes Cellular Invasion and Placental Colonization
TL;DR: FadA plays an important role in F. nucleatum colonization in vivo and may be a therapeutic target for preventing F.ucleatum colonization of the host, according to previous studies.