Akinobu Ito

TL;DR: It is likely that the observed resistance of bioFilms can be attributed to formation of ampicillin-resistant subpopulations in the deeper layers of mature biofilms but not in young colony biofilm and that the production and resistance of the subpopulation were aided by biofilm-specific phenotypes, like slow growth and induction of rpoS-mediated stress responses.

TL;DR: It is concluded that cefIDERocol forms a chelating complex with iron, which is actively transported into P. aeruginosa cells via iron transporters, resulting in potent antibacterial activity of cefiderocol against P.aerug inosa.

TL;DR: Cefiderocol, a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of Enterobacteriaceae and nonfermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.

TL;DR: This is the first report to demonstrate that S-649266, a novel siderophore cephalosporin, has significant antimicrobial activity against Enterobacteriaceae, including strains that produce carbapenemases such as KPC and NDM-1.

TL;DR: Its stability against clinically relevant carbapenemases was investigated and NDM-1 hydrolyzed meropenem 3-fold faster than S-649266 at 200 μM.