A
Akio Hoshi
Researcher at National Cancer Research Institute
Publications - 166
Citations - 2133
Akio Hoshi is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Clonogenic assay & Deoxyuridine. The author has an hindex of 20, co-authored 166 publications receiving 2090 citations. Previous affiliations of Akio Hoshi include University of Tokyo.
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Antitumor activity of 1,2-diaminocyclohexane--platinum complexes against sarcoma-180 ascites form.
TL;DR: Among the platinum complexes tested, oxalato(cis-1,2-diminocyclohexane)platinum had a remarkably high therapeutic index and modification of the nonleaving group as well as that of the leaving group is important in order to find better antitumor platinum complexes.
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Relationship between Development of Diarrhea and the Concentration of SN-38, an Active Metabolite of CPT-11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT-11
TL;DR: Serial determination of CPT‐11 and 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), with the use of an on‐line solid extraction HPLC system, demonstrated that much higher levels of the compounds are retained in the intestine and the blood plasma after five consecutive daily injections than after a single injection.
Journal Article
In vivo antitumor activity of multiple injections of recombinant interleukin 2, alone and in combination with three different types of recombinant interferon, on various syngeneic murine tumors.
TL;DR: It is demonstrated that combination therapies of rHIL2 and rIFN-alpha A/D or -beta can function synergistically in the various s.c. established murine tumor systems and give further evidence in support of their clinical potential.
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Time-schedule dependency of the inhibiting activity of various anticancer drugs in the clonogenic assay.
Yuka Matsushima,Fumihiko Kanzawa,Akio Hoshi,Shimizu E,Hiroaki Nomori,Yasutsuna Sasaki,Nagahiro Saijo +6 more
TL;DR: It is necessary to test these drugs in the assay by 24-h exposure for a more accurate assessment of their antitumor activity, as the effect of the schedule-dependent drugs was underestimated in the same conditions.
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Analysis of metastatic spread and growth of tumor cells in mice with depressed natural killer activity by anti-asialo GMl antibody or anticancer agents
Nagahiro Saijo,Akira Ozaki,Beppu Y,Kenji Takahashi,J. Fujita,Y. Sasaki,H. Nomori,M. Kimata,Shimizu E,Akio Hoshi +9 more
TL;DR: It can be concluded that NK cells have a key role in the control of metastases of malignant disease, and that support of NK activity is very important for the prevention of metastase prevention.