M
Masaaki Iigo
Researcher at Nagoya City University
Publications - 123
Citations - 4058
Masaaki Iigo is an academic researcher from Nagoya City University. The author has contributed to research in topics: Lactoferrin & Oral administration. The author has an hindex of 34, co-authored 123 publications receiving 3831 citations. Previous affiliations of Masaaki Iigo include National Cancer Research Institute & Kansai Medical University.
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Cancer Prevention by Natural Compounds
Hiroyuki Tsuda,Yutaka Ohshima,Hiroshi Nomoto,Ken-ichi Fujita,Eiji Matsuda,Masaaki Iigo,Nobuo Takasuka,Malcolm A. Moore +7 more
TL;DR: Natural agents are advantageous for application to humans because of their combined mild mechanism and here they are reviewed based on in vivo studies with reference to their structures, sources and mechanisms of action.
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Antitumor activity of 1,2-diaminocyclohexane--platinum complexes against sarcoma-180 ascites form.
TL;DR: Among the platinum complexes tested, oxalato(cis-1,2-diminocyclohexane)platinum had a remarkably high therapeutic index and modification of the nonleaving group as well as that of the leaving group is important in order to find better antitumor platinum complexes.
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Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development.
Tetsuyuki Takahashi,Nobuo Takasuka,Masaaki Iigo,Masaki Baba,Hoyoku Nishino,Hiroyuki Tsuda,Toru Okuyama +6 more
TL;DR: Evidence is presented that ILTG markedly decreases both prostaglandin E2 (PGE2) and nitric oxide (NO) production in RAW264.7 mouse macrophage cells, and in vivo administration of ILTG inhibited the induction of preneoplastic aberrant crypt foci in the male F344 rat colon.
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Relationship between Development of Diarrhea and the Concentration of SN-38, an Active Metabolite of CPT-11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT-11
TL;DR: Serial determination of CPT‐11 and 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), with the use of an on‐line solid extraction HPLC system, demonstrated that much higher levels of the compounds are retained in the intestine and the blood plasma after five consecutive daily injections than after a single injection.
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Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin.
TL;DR: Results suggest that enhanced production of IL‐18 and IFN‐γ and caspase‐1 induction by treatment with bLF may be important for elevation of intestinal mucosal immunity.