An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

Analyte Monitoring Device And Methods Of Use

Micromachining technology was used to prepare chemical analysis systems on glass chips (1 centimeter by 2 centimeters or larger) that utilize electroosmotic pumping to drive fluid flow and electrophoretic separation to distinguish sample components. Capillaries 1 to 10 centimeters long etched in the glass (cross section, 10 micrometers by 30 micrometers) allow for capillary electrophoresis-based separations of amino acids with up to 75,000 theoretical plates in about 15 seconds, and separations of about 600 plates can be effected within 4 seconds. Sample treatment steps within a manifold of intersecting capillaries were demonstrated for a simple sample dilution process. Manipulation of the applied voltages controlled the directions of fluid flow within the manifold. The principles demonstrated in this study can be used to develop a miniaturized system for sample handling and separation with no moving parts.

https://science.sciencemag.org/content/sci/261/5123/895.full.pdf

Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip

Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip

Over 7,000 peer reviewed articles have been published on electrochemical glucose assays and sensors over recent years. Their number makes a full review of the literature, or even of the most recent advances, impossible. Nevertheless, this chapter should acquaint the reader with the fundamentals of the electrochemistry of glucose and provide a perspective of the evolution of the electrochemical glucose assays and monitors helping diabetic people, who constitute about 5 % of the world’s population. Because of the large number of diabetic people, no assay is performed more frequently than that of glucose. Most of these assays are electrochemical. The reader interested also in nonelectrochemical assays used in, or proposed for, the management of diabetes is referred to a 2007 excellent review of Kondepati and Heise [1].

Electrochemical glucose sensors and their applications in diabetes management.

A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

Subcutaneous glucose electrode

An optical wiring substrate provides a slab optical waveguide having a refractive index different from a refractive index of other surrounding portions and a planar convex lens being provided continuously to a tip portion of an optical path of an optical wave guide including a core and cladding and formed on a substrate. The optical path of light passing through the planar convex lens is converted approximately by 90° with a mirror. The light reflected with the mirror is made as parallel light rays by use of a cylindrical lens.

Optical wiring substrate, method of manufacturing optical wiring substrate and multilayer optical wiring

A small size apparatus for measuring and recording acceleration comprises an acceleration sensor, an A/D converter which converts the output signal of the acceleration sensor to a digital signal, a control element which processes the digital signal, a detachable external memory device which stores data of a change in acceleration and, a battery for supplying electric power to the sensor, the A/D converter, the control element and the external memory device. The small size apparatus is mounted on a moving body to be measured and the entire small size apparatus is driven by the battery. The correct attachment of the external memory device is detected by steps of writing data into a special address, reading the data out thereafter, and comparing the written data and read data. When the read data coincides with the written data, it is judged that the external memory device is correctly attached.

Small size apparatus for measuring and recording acceleration

We have fabricated a miniature Clark oxygen electrode using micromachining. A glass substrate with a silver working electrode, gold counter electrode and Ag/AgCl reference electrode is bonded to a silicon substrate by field-assisted bonding. The substrate has anisotropically etched grooves to provide small cavities to accommodate an electrolyte solution. The oxygen-permeable membrane is made from FEP and affixed thermally to the substrate. The 90% response time is an average 30 s, the residual current at zero oxygen concentration is negligible and we obtain a very good linear calibration curve. Improving the FEP membrane adhesion gives an oxygen electrode capable of tolerating sterilization by steam. The oxygen electrode operates stably for 10 h. The electrode lifetime can be extended to 30 h by impregnating the electrolyte solution in a gel.

Micromachined Clark oxygen electrode

Preparation of biopolymer crystals is made automatic by an apparatus comprising a reactor system, a solution liquid supply system, temperature control system, and a control unit controlling the supply system and the temperature control system, and preferably, an image recording system.

Akio Sugama

Papers

Optical wiring substrate, method of manufacturing optical wiring substrate and multilayer optical wiring

Small size apparatus for measuring and recording acceleration

Micromachined Clark oxygen electrode

Automated biopolymer crystal preparation apparatus

A miniature Clark-type oxygen electrode using a polyelectrolyte and its application as a glucose sensor.