A
Akira Kotani
Researcher at Tokyo University of Pharmacy and Life Sciences
Publications - 102
Citations - 1588
Akira Kotani is an academic researcher from Tokyo University of Pharmacy and Life Sciences. The author has contributed to research in topics: High-performance liquid chromatography & Detection limit. The author has an hindex of 20, co-authored 90 publications receiving 1399 citations. Previous affiliations of Akira Kotani include University of Tokyo & Chiba University.
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Journal ArticleDOI
Estimation of the antioxidant activities of flavonoids from their oxidation potentials.
TL;DR: A quantitative structure-activity relationship was obtained to describe the AA of flavonoids, and IC50 represents the concentration for 50% inhibition of LPO, and P represents the octanol/water partition coefficient.
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Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam.
Masataka Nishikawa,Noritaka Ariyoshi,Akira Kotani,Itsuko Ishii,Hiroyoshi Nakamura,Hiromitsu Nakasa,Mayuri Ida,Hideo Nakamura,Nobuhito Kimura,Maharu Kimura,Atsushi Hasegawa,Fumiyo Kusu,Shigeru Ohmori,Kazuyoshi Nakazawa,Mitsukazu Kitada +14 more
TL;DR: The studies indicate that subchronic ingestion of GTE or GSE may alter the pharmacokinetics of MDZ, and the effects ofGTE on CYP3A activity appear opposite between liver and small intestine, which could not be predicted from in vitro experiments.
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Relationship of electrochemical oxidation of catechins on their antioxidant activity in microsomal lipid peroxidation.
TL;DR: Two important characteristics determining catechin antioxidant activity are suggested, namely the ease of oxidation and the lipophilicity.
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HPLC with electrochemical detection to examine the pharmacokinetics of baicalin and baicalein in rat plasma after oral administration of a Kampo medicine
TL;DR: Based on the time courses of the concentrations of the free and conjugated forms of baicalin and baicalein in rat plasma after oral administration of Saiko-keishi-to, the pharmacokinetic parameters of C(max), t(max, and AUC(0-6 h) were obtained.
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Determination of Short-chain Fatty Acids in Rat and Human Feces by High-Performance Liquid Chromatography with Electrochemical Detection
TL;DR: The present method was characterized by reproducibility with the simple and rapid procedure without derivatization of analytes, and it has the potential for clinical and biomedical applications.