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Alain Gobert
Publications - 42
Citations - 3488
Alain Gobert is an academic researcher. The author has contributed to research in topics: Agonist & Serotonin. The author has an hindex of 29, co-authored 42 publications receiving 3377 citations.
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Journal ArticleDOI
The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways
Millan Mark,Alain Gobert,Françoise Lejeune,Anne Dekeyne,Adrian Newman-Tancredi,Valérie Pasteau,Jean-Michel Rivet,Didier Cussac +7 more
TL;DR: In contrast to melatonin, agomelatine behaves as an antagonist at 5- HT2B and 5-HT2C receptors: blockade of the latter reinforces frontocortical adrenergic and dopaminergic transmission.
Journal Article
(1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists.
TL;DR: It is demonstrated that 5-HT2A receptors mediate HTW in rats and that both D1 and D2 receptors as well as (postsynaptic) 5- HT1A receptors play a role in their expression.
Journal ArticleDOI
Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release
Alain Gobert,Jean-Michel Rivet,Valérie Audinot,Adrian Newman-Tancredi,Laetitia Cistarelli,Mark Millan +5 more
TL;DR: There is a complex pattern of reciprocal autoreceptor and heteroceptor control of monoamine release in the frontal cortex of freely-moving rats using a novel and exceptionally sensitive method of high-performance liquid chromatography coupled to coulometric detection.
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Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states.
Millan Mark,Adrian Newman-Tancredi,Valérie Audinot,Didier Cussac,Françoise Lejeune,Jean-Paul Nicolas,Francis Cogé,Jean-Pierre Galizzi,Jean A. Boutin,Jean-Michel Rivet,Anne Dekeyne,Alain Gobert +11 more
TL;DR: The α2‐AR antagonist properties of yohimbine increase DA and NAD levels both alone and in association with fluoxetine, whereas fluparoxan selectively enhances hippocampal noradrenaline (NAD) turnover and enhances striatal dopamine turnover and suppresses striatal turnover of 5‐HT.
Journal ArticleDOI
Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram.
M.J. Millan,Alain Gobert,J. ‐M. Rivet,A. Adhumeau-Auclair,Cussac Didier,Adrian Newman-Tancredi,A. Dekeyne,Jean-Paul Nicolas,Françoise Lejeune +8 more
TL;DR: In contrast to citalopram, mirtazapine reinforces frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission, and reflects antagonist properties at α2A‐AR and 5‐HT2C receptors.