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Anne Dekeyne
Publications - 101
Citations - 4067
Anne Dekeyne is an academic researcher. The author has contributed to research in topics: Agonist & Serotonin. The author has an hindex of 33, co-authored 101 publications receiving 3884 citations.
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Journal ArticleDOI
The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways
Millan Mark,Alain Gobert,Françoise Lejeune,Anne Dekeyne,Adrian Newman-Tancredi,Valérie Pasteau,Jean-Michel Rivet,Didier Cussac +7 more
TL;DR: In contrast to melatonin, agomelatine behaves as an antagonist at 5- HT2B and 5-HT2C receptors: blockade of the latter reinforces frontocortical adrenergic and dopaminergic transmission.
Journal ArticleDOI
Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo
TL;DR: The data suggest that 5-HT2C receptors exert a tonic, inhibitory influence upon frontocortical dopaminergic and adrenergic, but not serotonergic, transmission.
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Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade
TL;DR: In contrast to melatonin, and reflecting blockade of 5-HT2C receptors, agomelatine is active in several models of anxiolytic properties in rodents and differs from that of benzodiazepines from which it may also be distinguished by its contrasting influence on corticolimbic monoaminergic pathways.
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Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states.
Millan Mark,Adrian Newman-Tancredi,Valérie Audinot,Didier Cussac,Françoise Lejeune,Jean-Paul Nicolas,Francis Cogé,Jean-Pierre Galizzi,Jean A. Boutin,Jean-Michel Rivet,Anne Dekeyne,Alain Gobert +11 more
TL;DR: The α2‐AR antagonist properties of yohimbine increase DA and NAD levels both alone and in association with fluoxetine, whereas fluparoxan selectively enhances hippocampal noradrenaline (NAD) turnover and enhances striatal dopamine turnover and suppresses striatal turnover of 5‐HT.
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5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia
Julie Meffre,Julie Meffre,Séverine Chaumont-Dubel,Séverine Chaumont-Dubel,Clotilde Mannoury la Cour,Florence Loiseau,David J. G. Watson,Anne Dekeyne,Martial Séveno,Martial Séveno,Jean-Michel Rivet,Florence Gaven,Florence Gaven,Paul Déléris,Paul Déléris,Denis Hervé,Kevin C. F. Fone,Joël Bockaert,Joël Bockaert,Millan Mark,Philippe Marin,Philippe Marin +21 more
TL;DR: It is shown that 5‐HT6 receptors physically interact with several proteins of the mammalian target of rapamycin (mTOR) pathway, including mTOR, and recruitment of mTOR by prefrontal 5‐ HT6 receptors contributes to the perturbed cognition in schizophrenia.