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Alain Philippe Vasserot
Researcher at Buck Institute for Research on Aging
Publications - 4
Citations - 1016
Alain Philippe Vasserot is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: Senolytic & Antigen. The author has an hindex of 4, co-authored 4 publications receiving 712 citations.
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Journal ArticleDOI
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Ok-Hee Jeon,Chaekyu Kim,Chaekyu Kim,Remi-Martin Laberge,Marco Demaria,Marco Demaria,Sona Rathod,Alain Philippe Vasserot,Jae Wook Chung,Do Hun Kim,Yan Poon,Nathaniel David,Darren J. Baker,Jan M. van Deursen,Judith Campisi,Judith Campisi,Jennifer H. Elisseeff +16 more
TL;DR: It is found that SnCs accumulated in the articular cartilage and synovium after ACLT, and selective elimination of these cells attenuated the development of post-traumatic OA, reduced pain and increased cartilage development, which support the use of SnCs as a therapeutic target for treating degenerative joint disease.
Patent
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
Remi-Martin Laberge,Judith Campisi,Albert R. Davalos,Marco Demaria,Nathaniel David,Alain Philippe Vasserot,Darren J. Baker,Bennett G. Childs,James L. Kirkland,Tamar Tchkonia,Jan M. van Deursen,Jennifer H. Elisseeff,Chaekyu Kim,Ok-Hee Jeon,Allyson K. Palmer +14 more
TL;DR: In this paper, methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof are presented.
Patent
Immunogenic compositions for inducing an immune response for elimination of senescent cells
TL;DR: The immunogenic compositions provided in this article include at least one or more senescent cell-associated antigens and recombinant expression vectors comprising the polynucleotides for use in administering to a subject in need thereof.
Patent
Compositions and methods for treating senescence-associated diseases and disorders
Jose Alberto Lopez-Dominguez,Remi-Martin Laberge,Judith Campisi,Albert R. Davalos,Marco Demaria,Nathaniel David,Alain Philippe Vasserot,Darren J. Baker,Bennett G. Childs,James L. Kirkland,Tamar Tchkonia,Jan M. van Deursen,Yi Zhu +12 more