T
Tamar Tchkonia
Researcher at Mayo Clinic
Publications - 85
Citations - 7966
Tamar Tchkonia is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Senolytic. The author has an hindex of 25, co-authored 85 publications receiving 4974 citations. Previous affiliations of Tamar Tchkonia include Buck Institute for Research on Aging & University of Rochester.
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Journal ArticleDOI
Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders
Darren J. Baker,Tobias Wijshake,Tamar Tchkonia,Nathan K. LeBrasseur,Bennett G. Childs,Bart van de Sluis,James L. Kirkland,Jan M. van Deursen +7 more
TL;DR: Data indicate that cellular senescence is causally implicated in generating age-related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan.
Journal ArticleDOI
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.
Jamie N. Justice,Anoop M. Nambiar,Tamar Tchkonia,Nathan K. LeBrasseur,Rodolfo M. Pascual,Shahrukh K. Hashmi,Larissa G.P. Langhi Prata,Michal M. Masternak,Stephen B. Kritchevsky,Nicolas Musi,James L. Kirkland +10 more
TL;DR: The authors' first-in-humans open-label pilot supports study feasibility and provides initial evidence that senolytics may alleviate physical dysfunction in IPF, warranting evaluation of DQ in larger randomized controlled trials for senescence-related diseases.
Journal ArticleDOI
Cellular senescence drives age-dependent hepatic steatosis.
Mikolaj Ogrodnik,Satomi Miwa,Tamar Tchkonia,Dina Tiniakos,Dina Tiniakos,Caroline L. Wilson,Albert Lahat,Christopher P. Day,Christopher P. Day,Alastair D. Burt,Alastair D. Burt,Allyson K. Palmer,Quentin M. Anstee,Sushma Nagaraja Grellscheid,Jan H.J. Hoeijmakers,Jan H.J. Hoeijmakers,Sander Barnhoorn,Derek A. Mann,Thomas G. Bird,Wilbert P. Vermeij,James L. Kirkland,João F. Passos,Thomas von Zglinicki,Diana Jurk +23 more
TL;DR: It is demonstrated that cellular senescence drives hepatic Steatosis and elimination of senescent cells may be a novel therapeutic strategy to reduce steatosis.
Journal ArticleDOI
Targeting senescent cells enhances adipogenesis and metabolic function in old age
Ming Xu,Allyson K. Palmer,Husheng Ding,Megan M. Weivoda,Tamar Pirtskhalava,Thomas A. White,Anna Sepe,Kurt O. Johnson,Michael B. Stout,Nino Giorgadze,Michael D. Jensen,Nathan K. LeBrasseur,Tamar Tchkonia,James L. Kirkland +13 more
TL;DR: This study indicates targeting senescent cells or their products may alleviate age-related dysfunction of progenitors, adipose tissue, and metabolism.
Journal ArticleDOI
Senolytic drugs: from discovery to translation.
James L. Kirkland,Tamar Tchkonia +1 more
TL;DR: Early pilot trials of senolytics suggest they decrease senescent cells, reduce inflammation and alleviate frailty in humans, opening a new route for treating age‐related dysfunction and diseases.