Showing papers by "Alan Davison published in 1983"
TL;DR: In this paper, the pertechnetate ion with aqueous sodium dithionite was reduced to hexakis(alkyl isocyanide) technetium(I) hexafluorophosphate (Tc(CNR)/sub 6/)PF/sub 6/ (where R = tert-butyl, methyl, cyclohexyl, and phenyl), and the complexes were characterized by elemental analysis, optical, ir, and /sup 1/H NMR spectroscopy, conductance, cyclic voltammetry, and field des
Abstract: The complexes, hexakis(alkyl isocyanide) technetium(I) hexafluorophosphate (Tc(CNR)/sub 6/)PF/sub 6/ (where R = tert-butyl, methyl, cyclohexyl, and phenyl), have been prepared by reduction of the pertechnetate ion with aqueous sodium dithionite (Na/sub 2/S/sub 2/O/sub 4/) in the presence of the isocyanide ligands. These complexes have been characterized by elemental analysis, optical, ir, and /sup 1/H NMR spectroscopy, conductance, cyclic voltammetry, and field desorption mass spectrometry.
140 citations
Journal Article•
TL;DR: The nature of two technetium-labeled radiopharmaceutical components has been established by means of fast-atom-bombardment mass spectrometry (FABMS) in combination with carrier-added (CA) and no-carrier- added (NCA) reversed-phase high-pressure liquid chromatography (HPLC).
Abstract: The nature of two technetium-labeled radiopharmaceutical components has been established by means of fast-atom-bombardment mass spectrometry (FABMS) in combination with carrier-added (CA) and no-carrier-added (NCA) reversed-phase high-pressure liquid chromatography (HPLC). Negative-ion FABMS was used to determine that the epimers of Tc-CO2DADS are the oxo[N,N'-(1-carboxyethylene)-bis-(2-mercaptoacetimido)]technetate(V) ions; positive-ion FABMS showed that Tc-HIDA is bis[N-(2,6-dimethylphenyl-carbamoylmethyliminodiaceto]technetate(III).
28 citations
TL;DR: In this article, the ligand exchange reactions of various oxotechnetium(V) complexes with 1,2-dithiols have been investigated, and different mechanisms and/or intermediates are observed in each case.
Abstract: The ligand-exchange reactions of various oxotechnetium(V) complexes with 1,2-dithiols have been investigated. The complexes (TcO(OCH/sub 2/CH/sub 2/O)/sub 2/)/sup -/(1), (TcO(O/sub 2/C/sub 6/H/sub 4/)/sub 2/)/sup -/(2), and (TcO(SCH/sub 2/CH/sub 2/O)/sub 2/)/sup -/(3) all react with 2 equiv of 1,2-ethanedithiol to ultimately form (TcO(SCH/sub 2/CH/sub 2/S)/sub 2/)/sup -/(4). However, different mechanisms and/or intermediates are observed in each case. The reaction of 1 proceeds without evidence for the formation of intermediates. In the reaction of 2, an intermediate is detected, which is probably a mixed-ligand oxotechnetium monomer; and in the reaction of 3 the spectrum of the intermediate formed is similar to that of the dimer species ((TcO)/sub 2/(SCH/sub 2/CH/sub 2/S)/sub 3/) (5). The relation of these results to ligand-exchange reactions of 1,2-dithiols with citrate complexes of technetium is discussed. Reaction of 1,3-propanedithiol with (TcOCl/sub 4/)/sup -/ gives a compond formulated as ((TcO)/sub 2/(SCH/sub 2/CH/sub 2/CH/sub 2/S)/sub 3/), which does not react with further amounts of ligand to form the bis(1,3-dithiolato) monomer, as would be anticipated from the sequential formation of 4 from 5 in the reacton of (TcOCl/sub 4/)/sup -/ with 1,2-ethanedithiol.
18 citations
17 citations
9 citations
TL;DR: The synthesis, reactivity and molecular structure of a variety of technetium(V) completes are reviewed in this article, where they are most conveniently categorized on the basis of their oxotechnetium cores (a) TcO 3+ ; (b) trans -TcO 2 + ; and (c) linear Tc 2 O 3 4+ ).
Abstract: The synthesis, reactivity and molecular structure of a variety of technetium(V) completes are reviewed. The oxotechnetium(V) species are most conveniently categorized on the basis of their oxotechnetium cores (a) TcO 3+ ; (b) trans -TcO 2 + ; and (c) linear Tc 2 O 3 4+ . All contain a terminal Tc=O bond, and are spin-paired diamagnetic compounds.
4 citations
Patent•
26 Apr 1983
TL;DR: In this article, a complexe de coordination d'un liant isonitrile and d'Un radionucleide is presented, in which Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb et Ta, est utile en tant qu'agent diagnostic for l'etiquetage de liposomes ou de vesicules, and des cellules vivantes selectionnees contenant des membranes de lipides,
Abstract: Un complexe de coordination d'un liant isonitrile et d'un radionucleide tel que Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb et Ta, est utile en tant qu'agent diagnostic pour l'etiquetage de liposomes ou de vesicules, et des cellules vivantes selectionnees contenant des membranes de lipides, tels que des caillots sanguins, des tissus du myocarde, des tissus de la vesicule biliaire, etc.