Alan F. Gasiecki

TL;DR: A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported, generating compounds of significant molecular complexity from simple starting materials in an expedient fashion with excellent yields.

TL;DR: In this paper, the authors proposed a method to provide compounds which inhibit specific combinations of kinases or target kinase pathways, such as GSK-3, Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim1 and nek2.

TL;DR: In this article, the authors present compounds of the formula Ar1-Q-Ar2-Y-R-Z and pharmaceutically acceptable salts thereof wherein Ar?1 and Ar2? are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an alternatively substituted monocyclic or bicycle-containing heteroaromatic moiety, R is an alkylene moiety; Y is a linking moiety capable of linking an ary

TL;DR: In this paper, a facile synthesis of fused triazolo imidazole derivatives by a van Leusen/alkyne-azide cycloaddition synthetic sequence is reported.

TL;DR: In this paper, a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the formula I, and methods of selectively inhibiting or antagonizing the α v β 3 integrin are discussed.