Alan H. Rebar

TL;DR: Airway enzymatic and cytologic responses were shown to be potentially useful as indicators of lung damage in toxicological screening programs.

TL;DR: In this paper, the authors examined lavage fluid from animals with a multifocal, terminal bronchiolitis induced by exposure to an oxidant gas for 48 hours and found that the most sensitive indicator of this type of injury was the neutrophil cell count, which showed a 10-fold increase even at the lowest level of exposure.

TL;DR: A rapid screening test for estimating the acute toxicity level of substances in the lung has been developed and evaluated using metal salts as the toxic agents and showed a dose-dependent response in the airway, which allowed a rapid determination of the lung dose of metal salt which caused acute toxicity.

TL;DR: The American Association for Clinical Chemistry's Division of Animal Clinical Chemistry and the American Society for Veterinary Clinical Pathology formed a joint committee to provide expert recommendations for clinical pathology testing of laboratory species involved in subchronic and chronic nonclinical toxicity and safety studies as discussed by the authors.

TL;DR: Performing lavage in vivo, as compared to in vitro, did not greatly alter the lavage fluid except for a trend toward a higher level of sialic acid in fluid taken from the living animal.