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Alan R. Hauser
Researcher at Northwestern University
Publications - 142
Citations - 9208
Alan R. Hauser is an academic researcher from Northwestern University. The author has contributed to research in topics: Pseudomonas aeruginosa & Virulence. The author has an hindex of 45, co-authored 130 publications receiving 8184 citations. Previous affiliations of Alan R. Hauser include Winthrop-University Hospital & Children's Memorial Hospital.
Papers
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Journal ArticleDOI
The type III secretion system of Pseudomonas aeruginosa : infection by injection
TL;DR: This Review summarizes the current knowledge of P. aeruginosa type III secretion, including the secretion and translocation machinery, the regulation of this machinery, and the associated chaperones and effector proteins.
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Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa.
TL;DR: The results suggest that the P. aeruginosa type III secretion system is present in nearly all clinical and environmental isolates but that individual isolates and populations of isolates from distinct disease sites differ in their effector genotypes.
Journal ArticleDOI
Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa.
Alan R. Hauser,Enesha Cobb,María Bodí,Dolors Mariscal,Jordi Vallés,Joanne N. Engel,Jordi Rello +6 more
TL;DR: In patients with ventilator-associated pneumonia, type-III-secreting isolates were associated with worse clinical outcomes, suggesting that this secretion system plays an important role in human disease.
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Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression.
James M. Musser,Alan R. Hauser,Michael H Kim,Patrick M. Schlievert,Kimberlyn Nelson,R. K. Selander +5 more
TL;DR: The demonstration of a relatively high frequency of expression of exotoxin A among isolates recovered from toxic-shock-like syndrome patients in the United States was confirmed, and this association both within clones and among distantly related clones supports the hypothesis that exot toxin A is a causal factor in pathogenesis of this disease.
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Clinical Significance of Microbial Infection and Adaptation in Cystic Fibrosis
TL;DR: Current evidence supporting or refuting a role for the different microbes and their adaptations in contributing to poor clinical outcomes in cystic fibrosis is reviewed.