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Albert B. DeLeo
Researcher at University of Pittsburgh
Publications - 94
Citations - 8248
Albert B. DeLeo is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 40, co-authored 92 publications receiving 7965 citations.
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Journal ArticleDOI
Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity
Jose I. Mayordomo,Tatiana D. Zorina,Walter J. Storkus,Laurence Zitvogel,Christina M. Celluzzi,Louis D. Falo,Cornelis J. M. Melief,S. T. Ildstad,Wybe Martin Kast,Albert B. DeLeo +9 more
TL;DR: Treatment of animals bearing established macroscopic tumours with tumour peptide-pulsed dendritic cells resulted in sustained tumour regression and tumour-free status in more than 80% of cases, and support the clinical use of tumour Peptide-Pulsed Dendritic Cells as components in developing effective cancer vaccines and therapies.
Journal ArticleDOI
Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.
Laurence Zitvogel,Jose I. Mayordomo,Tjendimin Tjandrawan,Albert B. DeLeo,Martha R. Clarke,Michael T. Lotze,Walter J. Storkus +6 more
TL;DR: Using the immunogenic C3 (H-2b) tumor model in B6 mice, tumor peptide-pulsed DC therapy resulted in the erradication of established d14 tumors and long-term survival in 100% of treated animals.
Journal ArticleDOI
Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.
TL;DR: In this article, a protein with an apparent molecular weight of 53,000 in extracts of transformed BALB/c cells was detected in normal adult mouse fibroblasts, lymphoid cells, or hematopoietic cells or in mouse embryo cells.
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Tumor rejection antigens of chemically induced sarcomas of inbred mice.
TL;DR: In this paper, isolated membrane and cytosol fractions from two antigenically distinct BALB/c sarcomas, Meth A and CMS5, have TRA activity, and biochemical characterization of the active components from the cytosolic and plasma membranes of these two tumors identified a glycoprotein of Mr 96,000.
Journal ArticleDOI
Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells.
William H. Chambers,N L Vujanovic,Albert B. DeLeo,M W Olszowy,Ronald B. Herberman,John C. Hiserodt +5 more
TL;DR: An mAb is described that recognizes a triggering structure that is expressed on rat LGL/NK cells and A-LAK cells and is a useful tool for the study of NK cell ontogeny and function, and the development of cells with LAK activity from the NK cell compartment.