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Albert G. Hulst
Researcher at Netherlands Organisation for Applied Scientific Research
Publications - 47
Citations - 1801
Albert G. Hulst is an academic researcher from Netherlands Organisation for Applied Scientific Research. The author has contributed to research in topics: Sulfur mustard & Mass spectrometry. The author has an hindex of 26, co-authored 47 publications receiving 1714 citations.
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Journal ArticleDOI
Retrospective detection of exposure to organophosphorus anti-cholinesterases: Mass spectrometric analysis of phosphylated human butyrylcholinesterase
A. Fidder,Albert G. Hulst,Daan Noort,R. de Ruiter,M.J. van der Schans,Hendrik P. Benschop,Jan P. Langenberg +6 more
TL;DR: A novel and general procedure is presented for detection of organophosphate-inhibited human butyrylcholinesterase (HuBuChE), which is based on electrospray tandem mass spectrometric analysis of phosphylated nonapeptides obtained after pepsin digestion of the enzyme.
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Alkylation of human serum albumin by sulfur mustard in vitro and in vivo: mass spectrometric analysis of a cysteine adduct as a sensitive biomarker of exposure.
TL;DR: The analytical procedure could be successfully applied to the analysis of albumin samples from Iranian victims of the Iran-Iraq war and allowed a detection limit for in vitro exposure of human blood of 10 nM, which is 1 order of magnitude lower than that obtained by means of modified Edman degradation.
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Quantitative analysis of O-isopropyl methylphosphonic acid in serum samples of Japanese citizens allegedly exposed to sarin: estimation of internal dosage
Daan Noort,Albert G. Hulst,Dominique H. J. M. Platenburg,Martine Polhuijs,Hendrik P. Benschop +4 more
TL;DR: High levels of IMPA appear to correlate with low levels of residual butyrylcholinesterase activity in the samples and vice versa, and in several cases, the doses appeared to be substantially higher than the assumed lethal doses in man.
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Chemostat-based proteomic analysis of toluene-affected Pseudomonas putida S12
Rita J. M. Volkers,Ad L. De Jong,Albert G. Hulst,Ben L. M. van Baar,Jan A.M. de Bont,Jan Wery +5 more
TL;DR: A more detailed view of the effect of toluene on the intracellular energy management of P. putida S12 is yielded and several novel leads have been obtained for further targeted investigations.
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Identification of chemicals related to the chemical weapons convention during an interlaboratory proficiency test
Edwin W. J. Hooijschuur,Albert G. Hulst,Ad L. De Jong,Leo P. J. De Reuver,Simon H. Van Krimpen,Ben L. M. van Baar,Eric R. J. Wils,Charles E. Kientz,Udo A. Th. Brinkman +8 more
TL;DR: In order to test the ability of laboratories to detect and identify chemicals related to the Chemical Weapons Convention (CWC), the Technical Secretariat of the Organisation for the Prohibition of Chemical Weapons organises proficiency tests as discussed by the authors.