A
Alberto Carignano
Researcher at University of Washington
Publications - 15
Citations - 226
Alberto Carignano is an academic researcher from University of Washington. The author has contributed to research in topics: Self-healing hydrogels & Gene regulatory network. The author has an hindex of 6, co-authored 14 publications receiving 100 citations. Previous affiliations of Alberto Carignano include University of Cambridge & Microsoft.
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Journal ArticleDOI
Microbial single-cell RNA sequencing by split-pool barcoding
Anna Kuchina,Leandra M. Brettner,Luana Paleologu,Charles M. Roco,Alexander B. Rosenberg,Alberto Carignano,Ryan Kibler,Matthew Hirano,R. William DePaolo,Georg Seelig +9 more
TL;DR: Examining B. subtilis transcriptional patterns revealed that a small fraction of cells grown in laboratory medium express a myo-inositol catabolism pathway, thus highlighting how microSPLiT can identify rare cellular states.
Posted ContentDOI
Microbial single-cell RNA sequencing by split-pool barcoding
Anna Kuchina,Leandra M. Brettner,Luana Paleologu,Charles M. Roco,Alexander B. Rosenberg,Alberto Carignano,Ryan Kibler,Matthew Hirano,R. William DePaolo,Georg Seelig +9 more
TL;DR: This work introduces microSPLiT, a low cost and high-throughput scRNA-seq method that works for gram-negative and gram-positive bacteria and can resolve transcriptional states that remain hidden at a population level.
Journal ArticleDOI
Dynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator.
Laurent Mombaerts,Alberto Carignano,Fiona C. Robertson,Timothy J. Hearn,Jin Junyang,David Hayden,Zoe Rutterford,Carlos Takeshi Hotta,Katherine E Hubbard,Marti Ruiz C Maria,Ye Yuan,Matthew A. Hannah,Jorge Goncalves,Jorge Goncalves,Alex A. R. Webb +14 more
TL;DR: This work developed a systematic and practical modeling framework based on the identification and comparison of gene regulatory dynamics that identified key transcriptional regulatory mechanisms of circadian period and uncovered the role of blue light in the response of the circadian oscillator to nicotinamide.
Proceedings ArticleDOI
Identifying progressive gene network perturbation from single-cell RNA-seq data
TL;DR: A computational approach, called PIPER (ProgressIve network PERturbation), to identify the perturbed genes that drive differences in the gene regulatory network across different points in a biological progression and is able to predict known key regulators of differentiation on real scRNA-Seq datasets.
Journal ArticleDOI
Poly(alkyl glycidyl ether) hydrogels for harnessing the bioactivity of engineered microbes
TL;DR: These yeast-laden hydrogel inks for the direct-write 3D printing of cuboidal lattices for immobilized whole-cell catalysis represent an attractive opportunity for whole- cell catalysis of other high-value products in a sustainable and continuous manner.