Aldo Badiani

TL;DR: Factors that affect whether tolerance and/or sensitization to the various effects of drugs will develop and be expressed are concerned, and with the variety and levels of mechanisms responsible for tolerance and sensitization under different conditions of exposure.

TL;DR: It is argued that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.

TL;DR: It is concluded that psychomotor sensitization is not an inevitable consequence of exposure to psychostimulant drugs, but is the result of interactions amongst the pharmacological actions of drugs and the circumstances surrounding drug administration.

TL;DR: It seems that environmental novelty alters the neurobiological effects of amphetamine independently of the primary neuropharmacological actions of this drug in the striatum.

TL;DR: Sensitization to the psychomotor activating effects of both amphetamine and cocaine is enhanced in a NOVEL environment; this phenomenon appears to be independent of the effects of the NOvel environment on the acute response to these drugs; and a robust conditioned psychology response to contextual cues develops only when cocaine treatments are given in the NOVEL test environment.