Alejandro Beceiro

TL;DR: This review considers how bacterial virulence and fitness are affected by antibiotic resistance and also how the relationship between virulent and resistance is affected by different genetic mechanisms and by the most prevalent global responses.

TL;DR: While Colistin resistance in A. baumannii confers a clear selective advantage in the presence of colistin treatment, it causes a noticeable cost in terms of overall fitness and virulence, with a more striking reduction associated with LPS loss than with phosphoethanolamine addition.

TL;DR: In the absence of availability of molecular biology techniques, the cefoxitin disc was the best predictor of methicillin resistance in S. aureus from among the techniques tested.

TL;DR: The results suggest that in addition to AmpC, efflux pumps, and OprD, the modification of PBP patterns appears to play a role in the in vivo emergence of PBLR strains, which still conserve certain susceptibility to the new antipseudomonal cephalosporin ceftolozane.

TL;DR: The crystal structure of OXA-24 is determined and it is shown that the carbapenem's substrate specificity is determined by a hydrophobic barrier that is established through the specific arrangement of the Tyr-112 and Met-223 side chains, which define a tunnel-like entrance to the active site.