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Alessandra Brambati
Researcher at New York University
Publications - 2
Citations - 87
Alessandra Brambati is an academic researcher from New York University. The author has contributed to research in topics: DNA & Homologous recombination. The author has an hindex of 2, co-authored 2 publications receiving 31 citations.
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DNA polymerase theta (Polθ) - an error-prone polymerase necessary for genome stability.
TL;DR: The multifunctionality of this enigmatic polymerase is reviewed, focusing on its role during DSB repair in mammalian cells and its impact on cancer genomes.
Journal ArticleDOI
Polθ reverse transcribes RNA and promotes RNA-templated DNA repair
Gurushankar Chandramouly,Jiemin Zhao,Shane McDevitt,Timur Rusanov,Trung Hoang,Nikita Borisonnik,Taylor Treddinick,Felicia Wednesday Lopezcolorado,Tatiana Kent,Labiba A. Siddique,Joseph S. Mallon,Jacklyn Huhn,Zainab Shoda,Ekaterina Kashkina,Alessandra Brambati,Jeremy M. Stark,Xiaojiang S. Chen,Richard T. Pomerantz +17 more
TL;DR: The 3.2-dimensional crystal structure of human replicative DNA polymerases (Polθ) on a DNA/RNA primer-template with bound deoxyribonucleotide reveals that the enzyme undergoes a major structural transformation within the thumb subdomain and forms multiple hydrogen bonds with template ribose 2′-hydroxyl groups like retroviral RTs as mentioned in this paper.