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Alessandra Calabrese
Publications - 2
Citations - 317
Alessandra Calabrese is an academic researcher. The author has contributed to research in topics: Gene silencing & RNA interference. The author has an hindex of 2, co-authored 2 publications receiving 286 citations.
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Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
Frédéric Colland,Etienne Formstecher,Xavier Jacq,Céline Reverdy,Cecile Planquette,Susan Conrath,Virginie Trouplin,Julie Bianchi,Vasily N. Aushev,Jacques Camonis,Alessandra Calabrese,Catherine Borg-Capra,Wolfgang Sippl,Vincent Collura,Guillaume Boissy,Jean-Christophe Rain,Philippe Guedat,Remi Delansorne,Laurent Daviet +18 more
TL;DR: HBX 41,108 is reported, a small-molecule compound that inhibits USP7 deubiquitinating activity with an IC50 in the submicromolar range, providing a structural basis for the development of new anticancer drugs.
Journal ArticleDOI
Combination of active and inactive siRNA targeting the mitotic kinesin Eg5 impairs silencing efficiency in several cancer cell lines.
Etienne Formstecher,Céline Reverdy,Mickael Cholay,Cecile Planquette,Virginie Trouplin,Heike Lehrmann,Sandra Aresta,Alessandra Calabrese,Khalil Arar,Laurent Daviet,Frédéric Colland +10 more
TL;DR: It is shown that presence of inactive Eg5 siRNA in a pool dramatically decreases knockdown efficacy in a cell line- and dose-dependent manner and indicates that combination of siRNA may not increase but instead decrease silencing efficiency.