C
Catherine Borg-Capra
Publications - 4
Citations - 320
Catherine Borg-Capra is an academic researcher. The author has contributed to research in topics: Proteases & Ubiquitin. The author has an hindex of 2, co-authored 4 publications receiving 289 citations.
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Journal ArticleDOI
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
Frédéric Colland,Etienne Formstecher,Xavier Jacq,Céline Reverdy,Cecile Planquette,Susan Conrath,Virginie Trouplin,Julie Bianchi,Vasily N. Aushev,Jacques Camonis,Alessandra Calabrese,Catherine Borg-Capra,Wolfgang Sippl,Vincent Collura,Guillaume Boissy,Jean-Christophe Rain,Philippe Guedat,Remi Delansorne,Laurent Daviet +18 more
TL;DR: HBX 41,108 is reported, a small-molecule compound that inhibits USP7 deubiquitinating activity with an IC50 in the submicromolar range, providing a structural basis for the development of new anticancer drugs.
Patent
Novel cysteine protease inhibitors and their therapeutic applications
Philippe Guedat,Guillaume Boissy,Catherine Borg-Capra,Frédéric Colland,Laurent Daviet,Etienne Formstecher,Xavier Jacq,Jean-Christophe Rain,Rerni Delansorne,Stefania Vallese,Matteo Colombo +10 more
TL;DR: In this article, the present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use, and their application in the treatment of cancer and other diseases.