Alessandro Paiardini

TL;DR: A number of new MODELLER functionalities have also been implemented, including SALIGN, modeling of quaternary structures, DOPE scores, disulfide bond modeling and choice of heteroatoms to be included in the final model.

TL;DR: The results suggest that haloadaptation strategy in the presence of molar salt concentration, but not of osmolytes, necessitates a weakening of the hydrophobic interactions, in particular at the level of conservedHydrophobic contacts.

TL;DR: A simple and intuitive interface, PyMod has been developed, to show how the integration of the individual steps required for homology modeling and sequence/structure analysis within the PyMOL framework can hugely simplify these tasks.

TL;DR: The metabolic transformations occurring in the prostate from the normal cell to the metastasis are recapitulate, highlighting the role of the microenvironment and summarizing what is known on the molecular mechanisms involved in the process.

TL;DR: Analysis of three-dimensional data coupled to a kinetic study allows to identify the structural determinants of the open/close conformational change occurring upon PLP binding and thereby propose a model for the preferential degradation of the apoenzymes of Group II decarboxylases.