Alex V. Pickering

TL;DR: TRIM8 is also upregulated in SJIA monocytes, and augments macrophage IFN-γ response in vitro, providing both a candidate molecular mechanism and potential therapeutic target for monocyte hyper-responsiveness to IFNγ in cytokine storms including MAS.

TL;DR: A meeting to integrate clinical and research findings in MAS and SJIA-LD brought together scientists, clinicians, parents and FDA representatives with the objectives to develop a shared understanding of this seemingly new pulmonary complication of SJIA.

TL;DR: In this paper, a secondary analysis of whole-blood gene expression microarrays using blood samples obtained from healthy controls and systemic juvenile idiopathic arthritis (JIA) patients at baseline and on day 3 after canakinumab treatment (GEO accession no. GSE80060).

TL;DR: This work proposes a new cross-modal small molecule retrieval task, designed to force a model to learn to associate the structure of a small molecule with the transcriptional change it induces, developed formally as multi-view alignment problem, and presents a coordinated deep learning approach.

TL;DR: A novel deep learning architecture is utilized to jointly train coordinated embeddings of chemical structures and transcriptional signatures by training neural networks in a coordinated manner such that learned chemical representations correlate most highly with the encodings of the transcriptional patterns they induce.