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Alexander Candelario
Researcher at Merck & Co.
Publications - 1
Citations - 150
Alexander Candelario is an academic researcher from Merck & Co.. The author has contributed to research in topics: Lewis acids and bases & Condensation reaction. The author has an hindex of 1, co-authored 1 publications receiving 142 citations.
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Efficient Synthesis of NK1 Receptor Antagonist Aprepitant Using a Crystallization-Induced Diastereoselective Transformation†
Karel M. J. Brands,Joseph F. Payack,Jonathan D. Rosen,Todd D. Nelson,Alexander Candelario,Mark A. Huffman,Matthew M. Zhao,Jing Li,Bridgette Craig,Zhiguo J. Song,David M. Tschaen,Karl B. Hansen,Paul N. Devine,Philip J. Pye,Kai Rossen,Peter G. Dormer,Robert A. Reamer,Christopher J. Welch,David J. Mathre,Nancy N. Tsou,James M. McNamara,Paul J. Reider +21 more
TL;DR: An efficient stereoselective synthesis of the orally active NK(1) receptor antagonist Aprepitant is described, and the targeted clinical candidate was obtained in 55% overall yield over the longest linear sequence.