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Alexander H. Staudacher
Researcher at University of South Australia
Publications - 31
Citations - 522
Alexander H. Staudacher is an academic researcher from University of South Australia. The author has contributed to research in topics: Cancer & Immunology. The author has an hindex of 11, co-authored 27 publications receiving 337 citations. Previous affiliations of Alexander H. Staudacher include Flinders University & South Australia Pathology.
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Journal ArticleDOI
Antibody drug conjugates and bystander killing: is antigen-dependent internalisation required?
TL;DR: The role of bystander killing by ADCs is examined and the emerging evidence of how this can occur independently of internalisation is explored.
Journal ArticleDOI
The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the La-specific antibody APOMAB®
Alexander H. Staudacher,Alexander H. Staudacher,Alexander H. Staudacher,Fares Al-Ejeh,Cara K. Fraser,Jocelyn M. Darby,Jocelyn M. Darby,David Roder,Andrew Ruszkiewicz,Andrew Ruszkiewicz,Andrew Ruszkiewicz,Jim Manavis,Michael P. Brown +12 more
TL;DR: The La antigen represents a dead cancer cell-specific target in lung cancer, and DAB4 specifically targeted tumour tissue in vivo, particularly after chemotherapy, which may have broad clinical utility.
Journal ArticleDOI
Diversity of cancer stem cells in head and neck carcinomas: The role of HPV in cancer stem cell heterogeneity, plasticity and treatment response.
TL;DR: Understanding how HPV positive and negative aetiologies affect CSC response to treatment and tumour plasticity will facilitate their use for greater treatment individualisation.
Journal ArticleDOI
In vitro investigation of head and neck cancer stem cell proportions and their changes following X-ray irradiation as a function of HPV status.
Paul Reid,P. A. Wilson,Yanrui Li,Loredana G. Marcu,Loredana G. Marcu,Alexander H. Staudacher,Michael P. Brown,Michael P. Brown,Michael P. Brown,Eva Bezak,Eva Bezak +10 more
TL;DR: CSC proportions in both HNSCC cell lines were elevated after exposure and varied with time post irradiation, and UM-SCC-47 displayed significant plasticity in repopulating the CSC phenotype in depleted cultures, which was not seen in UM- SCC-1.
Journal ArticleDOI
Cancer cell detection device for the diagnosis of bladder cancer from urine.
Melanie MacGregor,Hanieh Safizadeh Shirazi,Kit Man Chan,Kola Ostrikov,Kym McNicholas,Alex Jay,Michael Chong,Alexander H. Staudacher,Thomas D. Michl,Aigerim Zhalgasbaikyzy,Michael P. Brown,Moein Navvab Kashani,Adam Di Fiore,Alex Grochowski,Stephen Robb,Simon Belcher,Jordan Y. Z. Li,Jonathan M. Gleadle,Krasimir Vasilev +18 more
TL;DR: A microfluidic-based platform for non-invasive diagnosis which combines the principle of PDD with whole cell immunocapture technology to detect bladder cancer cells shed in patient urine ex vivo is presented.