A
Alexander M. Klibanov
Researcher at Massachusetts Institute of Technology
Publications - 338
Citations - 41865
Alexander M. Klibanov is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Aqueous solution & Catalysis. The author has an hindex of 101, co-authored 338 publications receiving 40484 citations. Previous affiliations of Alexander M. Klibanov include Brandeis University & University of California, San Diego.
Papers
More filters
Journal ArticleDOI
Improving enzymes by using them in organic solvents
TL;DR: The technological utility of enzymes can be enhanced greatly by using them in organic solvents rather than their natural aqueous reaction media, and they have found numerous potential applications, some of which are already commercialized.
Journal ArticleDOI
Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis.
TL;DR: The relatively high transfection efficiency of polyethylenimine vectors has been hypothesized to be due to their ability to avoid trafficking to degradative lysosomes, and according to the proton sponge hypothesis, the buffering capacity of PEI leads to osmotic swelling and rupture of endosome, resulting in the release of the vector into the cytoplasm.
Journal ArticleDOI
Designing surfaces that kill bacteria on contact
TL;DR: On surfaces modified with N-hexylated poly(4-vinylpyridine), the numbers of viable cells of another Gram-positive bacterium, Staphylococcus epidermidis, as well as of the Gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli, dropped more than 100-fold compared with the original amino glass.
Journal ArticleDOI
Enzyme-catalyzed processes in organic solvents.
TL;DR: Lipases can catalyze several other processes in organic media including esterification, aminolysis, acyl exchange, thiotransesterification, and oximolysis; some of these reactions proceed to an appreciable extent only in nonaqueous solvents.
Journal ArticleDOI
Enzymatic catalysis in organic media at 100 degrees C
TL;DR: Porcine pancreatic lipase catalyzes the transesterification reaction between tributyrin and various primary and secondary alcohols in a 99 percent organic medium and exhibits a high catalytic activity at that temperature.