Alexander Thomas Mehlhorn

TL;DR: The stability of chondrogenic phenotype and the transdifferentiation potential of bone marrow-derived mesenchymal stem cells (MSCs) at distinct stages of differentiation are addressed to give a better understanding of the behavior of cartilage grafts affected by local factors of osteochondral transplantation sites in vivo.

TL;DR: Biologically relevant nanomechanical parameters contribute to the evaluation of stem cell differentiation, in view of increased deformability of stem cells after chondrogenic stimulation, and the control of small GTPases is promising for cartilage tissue engineering purposes ofstem cells.

TL;DR: Insulin-like growth factor–I is present in knees with circumscribed cartilage lesions in a size-dependent manner and smoking negatively influenced synovial cytokine expression related to cartilage metabolism, but pain perception was not altered.

TL;DR: BMP-2, BMP-7, and BMPR-1A were expressed in cartilage and synovia of knees with focal cartilage lesions and although defect localization and duration of symptoms decisively influence KOSS, there was no associated alteration of protein expression observed.

TL;DR: At a mid‐term follow‐up examination, gastrocnemius recession (Strayer) was shown to be an effective procedure to significantly improve ankle dorsiflexion, functionality, and pain symptoms and more attention should be given to the development of postoperative complications.