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Ingo H. Pilz
Researcher at University of Freiburg
Publications - 16
Citations - 1917
Ingo H. Pilz is an academic researcher from University of Freiburg. The author has contributed to research in topics: Haematopoiesis & Genetic enhancement. The author has an hindex of 9, co-authored 16 publications receiving 1808 citations. Previous affiliations of Ingo H. Pilz include University Medical Center Freiburg.
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Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.
Marion Ott,Manfred Schmidt,Kerstin Schwarzwaelder,Stefan Stein,Ulrich Siler,Ulrike Koehl,Hanno Glimm,K. Kühlcke,Andrea Schilz,Hana Kunkel,Sonja Naundorf,Andrea Brinkmann,Annette Deichmann,Marlene Fischer,Claudia R. Ball,Ingo H. Pilz,Cynthia E. Dunbar,Yang Du,Nancy A. Jenkins,Neal G. Copeland,Ursula Lüthi,Moustapha Hassan,Adrian J. Thrasher,Dieter Hoelzer,Christof von Kalle,Reinhard Seger,Manuel Grez +26 more
TL;DR: The results suggest that gene therapy in combination with bone marrow conditioning can be successfully used to treat inherited diseases affecting the myeloid compartment such as CGD.
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High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).
Manfred Schmidt,Kerstin Schwarzwaelder,Cynthia C. Bartholomae,Karim Zaoui,Claudia R. Ball,Ingo H. Pilz,Sandra Braun,Hanno Glimm,Christof von Kalle +8 more
TL;DR: The use of LAM-PCR analyses to identify 5′ long terminal repeat (LTR) retroviral vector adjacent genomic sequences and the reliability and robustness of this method results from the initial preamplification of the vector-genome junctions preceding nontarget DNA removal via magnetic selection.
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Bone marrow-derived cells contribute to infarct remodelling
Helge Möllmann,Holger Nef,Sawa Kostin,Christof von Kalle,Ingo H. Pilz,Michael Weber,Jutta Schaper,Christian W. Hamm,Albrecht Elsässer +8 more
TL;DR: BMC-derived fibroblast and myofibroblasts as well as neoangiogenesis significantly contribute to post-infarction scar formation and might be important in scar tissue remodelling.
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Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque
Ruth Seggewiss,Stefania Pittaluga,Rima Adler,F. Javier Guenaga,Cole J. Ferguson,Ingo H. Pilz,Byoung Y. Ryu,Brian P. Sorrentino,W. Scott Young,Robert E. Donahue,Christof von Kalle,Arthur W. Nienhuis,Cynthia E. Dunbar +12 more
TL;DR: It is reported that five years after transplantation with CD34+ cells transduced with a retroviral vector expressing enhanced green fluorescent protein (eGFP) and a drug-resistant variant of the dihydrofolate reductase gene (L22Y), a rhesus macaque developed a fatal myeloids sarcoma, a type of acute myeloid leukemia.
Journal ArticleDOI
Expression of BMP-receptor type 1A correlates with progress of osteoarthritis in human knee joints with focal cartilage lesions.
Hagen Schmal,Ingo H. Pilz,Alexander T. Mehlhorn,David Dovi-Akue,Christina Kirchhoff,Norbert P. Südkamp,Ulrike V. Gerlach,Philipp Niemeyer +7 more
TL;DR: The role of BMPR-1A as an indicator of OA progression in human knees with circumscribed cartilage lesions supports the role of BMP-2 and its receptor type 1A as a correlation between intra-articular expression of these proteins and the degree of osteoarthritis.