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Alexandra E. Rangel
Researcher at Stanford University
Publications - 10
Citations - 247
Alexandra E. Rangel is an academic researcher from Stanford University. The author has contributed to research in topics: Aptamer & Systematic evolution of ligands by exponential enrichment. The author has an hindex of 4, co-authored 8 publications receiving 153 citations. Previous affiliations of Alexandra E. Rangel include University of Utah.
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In vitro selection of an XNA aptamer capable of small-molecule recognition.
TL;DR: This research establishes the first example of an XNA aptamer of any kind to be evolved having affinity to a small-molecule target, as well as its high level of selectivity, as it is capable of binding OTA in a large background of competing biomolecules.
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Enhancing aptamer function and stability via in vitro selection using modified nucleic acids.
TL;DR: In this paper, a review of the development of nucleic acid aptamers has been presented, highlighting the improvements in aptamer function that have been realized through in vitro selection of non-natural nucleic acids.
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Engineering Aptamer Switches for Multifunctional Stimulus-Responsive Nanosystems
TL;DR: The use of nucleic acid as an externally controllable switching material has been explored in this article. But, it is still in its infancy, and there is a lot of work to be done in this area.
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Fluorescent RNA labeling using self-alkylating ribozymes.
Ashwani Sharma,Joshua J. Plant,Alexandra E. Rangel,Kirsten N. Meek,April J. Anamisis,Julie Hollien,Jennifer M. Heemstra +6 more
TL;DR: This work proposes a novel strategy in which a ribozyme acts to promote self-alkylation with a fluorophore, providing a robust, covalent linkage between the RNA and the fluorophile, and demonstrates that labeling is specific to the ribo enzyme sequences, as FIA does not react nonspecifically with RNA.
Journal ArticleDOI
RE-SELEX: restriction enzyme-based evolution of structure-switching aptamer biosensors
Aimee A. Sanford,Alexandra E. Rangel,Trevor A. Feagin,Robert G. Lowery,Hector S. Argueta-Gonzalez,Jennifer M. Heemstra +5 more
TL;DR: This research demonstrates the first homogenous, structure-switching aptamer selection that directly reports on biosensor capacity for the target and can be applied to a broad range of small-molecule targets.