A
Ashwani Sharma
Researcher at Indian Institute of Science
Publications - 13
Citations - 458
Ashwani Sharma is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: RNA & Nucleic acid. The author has an hindex of 6, co-authored 12 publications receiving 396 citations. Previous affiliations of Ashwani Sharma include University of Kentucky & University of Utah.
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Journal ArticleDOI
Stable RNA nanoparticles as potential new generation drugs for cancer therapy
Yi Shu,Fengmei Pi,Ashwani Sharma,Mehdi Rajabi,Farzin Haque,Dan Shu,Markos Leggas,B. Mark Evers,Peixuan Guo +8 more
TL;DR: This review summarizes the key studies that have led to the detailed understanding of RNA nanoparticle formation as well as chemical and thermodynamic stability issue and discusses the current challenges in the clinical application of RNA nanotechnology.
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Enzyme-linked small-molecule detection using split aptamer ligation
TL;DR: An aptamer-based analogue of the widely used sandwich enzyme-linked immunosorbent assay (ELISA) that demonstrates detection of cocaine at concentrations of 100 nM-100 μM in buffer and 1- 100 μM human blood serum and highlights the utility of covalently trapping split aptamer assembly events.
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Construction of RNA–Quantum Dot Chimera for Nanoscale Resistive Biomemory Application
TL;DR: The conjugated pRNA-3WJ-QD chimera exhibited an excellent electrical bistability signal for biomolescular memory function, demonstrating great potential for the development of resistive biomolecular memory and a nano-bio-inspired electronic device for information processing and computing.
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Fluorescent RNA labeling using self-alkylating ribozymes.
Ashwani Sharma,Joshua J. Plant,Alexandra E. Rangel,Kirsten N. Meek,April J. Anamisis,Julie Hollien,Jennifer M. Heemstra +6 more
TL;DR: This work proposes a novel strategy in which a ribozyme acts to promote self-alkylation with a fluorophore, providing a robust, covalent linkage between the RNA and the fluorophile, and demonstrates that labeling is specific to the ribo enzyme sequences, as FIA does not react nonspecifically with RNA.
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Controllable self-assembly of RNA dendrimers.
TL;DR: Upon incorporation of folate on the peripheral branches of the RNA dendrimers, the resulting constructs showed high binding and internalization into cancer cells, and may prove to be useful in many clinical settings.