Alexandra Lucas

TL;DR: Because of their anti-inflammatory nature, many of these poxvirus proteins hold promise as potential therapeutic agents for acute or chronic inflammatory conditions.

TL;DR: In rabbits infected with a mutant rabbitpox virus, there was an increased number of extravasating leukocytes in the deep dermis during the early phases of infection, suggesting that members of the T1/35kDa class of secreted viral proteins bind multiple members ofThe chemokine superfamily in vitro and modulate the influx of inflammatory cells into virus-infected tissues in vivo.

TL;DR: It is concluded that M-T7 functions early in infection to retard inflammatory cell migration into infected tissues and disrupt the communication between sentinel immune cells at the site of primary virus infection in the subdermis and lymphocytes in the secondary lymphoid organs, thereby disabling the host from mounting an effective cellular immune response.

TL;DR: Purified SERP-1, a virus-encoded secreted glycoprotein, reduces plaque growth after primary balloon-mediated injury and is associated with a focal reduction in macrophage infiltration immediately after injury.

TL;DR: Viral immunomodulatory proteins that have been tested as anti-inflammatory reagents in animal models of disease caused by excessive inflammation or hyperactivated immune pathways are reviewed.