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Alexandra Wolf
Researcher at University of Duisburg-Essen
Publications - 5
Citations - 121
Alexandra Wolf is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 3, co-authored 5 publications receiving 72 citations.
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Journal ArticleDOI
PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)
Philip Kranz,Fabian Neumann,Alexandra Wolf,Fabian Classen,Mosche Pompsch,Tobias Ocklenburg,Jennifer Baumann,Kirsten Janke,Melanie Baumann,Kirsten Goepelt,Helena Riffkin,Eric Metzen,Ulf Brockmeier +12 more
TL;DR: This study defines a new interface between metabolic redox signaling and PERK-dependent activation of the UPR and has the potential to influence future cancer therapies that target PERK signaling.
Journal ArticleDOI
Autophagy induced by ionizing radiation promotes cell death over survival in human colorectal cancer cells.
Fabian Classen,Philip Kranz,Helena Riffkin,Mosche Pompsch,Alexandra Wolf,Kirsten Göpelt,Melanie Baumann,Jennifer Baumann,Ulf Brockmeier,Eric Metzen +9 more
TL;DR: Results highlight that inhibition of autophagic pathways does not generally increase therapy success but may also lead to an unfavorable outcome especially under amino acid and oxygen restriction.
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Carotid body type I cells engage flavoprotein and Pin1 for oxygen sensing
André Bernardini,Alexandra Wolf,Ulf Brockmeier,Helena Riffkin,Eric Metzen,Amparo Acker-Palmer,Joachim Fandrey,Helmut Acker +7 more
TL;DR: It is postulate that hypoxia-induced changes in the Fp mediated redox ratio of the CB regulate the Pin1/p47phox tandem to alter Type I cell potassium channels and therewith CND.
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In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway
Tobias Ocklenburg,Fabian Neumann,Alexandra Wolf,Julia Vogel,Kirsten Göpelt,Melanie Baumann,Jennifer Baumann,Philip Kranz,Eric Metzen,Ulf Brockmeier +9 more
TL;DR: In this article, the role of disulfide isomerase ERp57 in cell growth was tested under oxygen depletion in the colorectal cancer cell line HCT116.
Journal ArticleDOI
Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress.
Philip Kranz,Christopher Sänger,Alexandra Wolf,Jennifer Baumann,Eric Metzen,Melanie Baumann,Kirsten Göpelt,Ulf Brockmeier +7 more
TL;DR: It is reported that the thiol oxidoreductase PDI is mandatory for activation of the PERK pathway in HEK293T as well as in human pancreatic, lung and colon cancer cells and it is demonstrated that PDI prevented degradation of activated PERK by the 26S proteasome and therefore contributes to maintained PERK signaling.