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Alfred G. Knudson
Researcher at Fox Chase Cancer Center
Publications - 83
Citations - 17847
Alfred G. Knudson is an academic researcher from Fox Chase Cancer Center. The author has contributed to research in topics: Cancer & Carcinogenesis. The author has an hindex of 40, co-authored 83 publications receiving 17230 citations. Previous affiliations of Alfred G. Knudson include University of Texas Health Science Center at Houston.
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Mutation and Cancer: Statistical Study of Retinoblastoma
TL;DR: The hypothesis is developed that retinoblastoma is a cancer caused by two mutational events, in the dominantly inherited form, one mutation is inherited via the germinal cells and the second occurs in somatic cells.
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Two genetic hits (more or less) to cancer.
TL;DR: Most cancers have many chromosomal abnormalities, both in number and in structure, whereas some show only a single aberration, which indicates that cancers can arise from small numbers of events that affect common cell birth and death processes.
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Mutation and Cancer: A Model for Human Carcinogenesis
TL;DR: A model for carcinogenesis is presented that provides a framework for understanding the roles of "spontaneous" events, hereditary factors, and environmental agents in human carcinogenesis and for interpreting experimental carcinogenesis.
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Antioncogenes and human cancer
TL;DR: The genes that have been cloned act at diverse points in the signal transduction pathway in cells, from the outer cell membranes to sites of gene transcription, in some cases as negative regulators of oncogene expression.