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Alfred G. Knudson
Researcher at Fox Chase Cancer Center
Publications - 83
Citations - 17847
Alfred G. Knudson is an academic researcher from Fox Chase Cancer Center. The author has contributed to research in topics: Cancer & Carcinogenesis. The author has an hindex of 40, co-authored 83 publications receiving 17230 citations. Previous affiliations of Alfred G. Knudson include University of Texas Health Science Center at Houston.
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Optimized procedures for microarray analysis of histological specimens processed by laser capture microdissection.
John J. Upson,Radka Stoyanova,Harry S. Cooper,Christos Patriotis,Eric Ross,Bruce M. Boman,Margie L. Clapper,Alfred G. Knudson,Alfonso Bellacosa +8 more
TL;DR: Results demonstrate that LCM‐derived tissue from histological specimens can generate abundant amounts of high‐quality aRNA for subsequent microarray analysis, and underscores the reliability of the micro array analysis of LCM-derived material.
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Cancer genetics, cytogenetics—defining the enemy within
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Mutation and cancer in man.
TL;DR: The rates of mutation in germ cells are the principal determinant of the incidence of genetically predisposed individuals, whereas the rate in somatic cells is the principaleterminant in those not sopredisposed.
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Genetics of Tumors of the Head and Neck
TL;DR: Two uncommon tumors of the head and neck first revealed primary roles for two classes of cancer genes (oncogenes, tumor suppressor genes) in the origin of human cancer.
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APC+/− alters colonic fibroblast proteome in FAP
Bhavinkumar B. Patel,Xin-Ming Li,Maketa P. Dixon,Elena L. Blagoi,Emmanuelle Nicolas,Steven H. Seeholzer,David Cheng,Yin A. He,Renata A. Coudry,Sharon Howard,Dawn M. Riddle,Harry S. Cooper,Bruce M. Boman,Peggy Conrad,James A. Crowell,Alfonso Bellacosa,Alfred G. Knudson,Anthony T. Yeung,Levy Kopelovich +18 more
TL;DR: The results indicate that heterozygosity for a mutant APC tumor suppressor gene alters the proteomes of both colon-derived normal fibroblasts in a gene-specific manner, consistent with a “one-hit” effect.