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JournalISSN: 1474-175X

Nature Reviews Cancer

About: Nature Reviews Cancer is an academic journal. The journal publishes majorly in the area(s): Cancer & Metastasis. It has an ISSN identifier of 1474-175X. Over the lifetime, 3571 publication(s) have been published receiving 795754 citation(s). The journal is also known as: Nature Reviews. Cancer. more

Topics: Cancer, Metastasis, Breast cancer more

Open accessJournal ArticleDOI: 10.1038/NRC3239
Drew M. Pardoll1Institutions (1)
Abstract: Immune checkpoints refer to the plethora of inhibitory pathways that are crucial to maintaining self-tolerance. Tumour cells induce immune checkpoints to evade immunosurveillance. This Review discusses the progress in targeting immune checkpoints, the considerations for combinatorial therapy and the potential for additional immune-checkpoint targets. more

Topics: Checkpoint Blockade Immunotherapy (60%), Immune checkpoint (60%), Immunosurveillance (54%) more

8,577 Citations

Journal ArticleDOI: 10.1038/NRC822
Jean Paul Thiery1Institutions (1)
Abstract: Without epithelial–mesenchymal transitions, in which polarized epithelial cells are converted into motile cells, multicellular organisms would be incapable of getting past the blastula stage of embryonic development. However, this important developmental programme has a more sinister role in tumour progression. Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states. more

6,032 Citations

Journal ArticleDOI: 10.1038/NRC1997
George A. Calin1, Carlo M. Croce1Institutions (1)
Abstract: MicroRNA (miRNA ) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein- coding genes involved in cancer. more

Topics: Oncomir (56%), microRNA (52%), Epigenetics (51%)

5,976 Citations

Journal ArticleDOI: 10.1038/NRC745
Mikala Egeblad1, Zena Werb1Institutions (1)
Abstract: Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with disappointing results. We now know, however, that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer. With this knowledge in hand, can we rethink the use of MMP inhibitors in the clinic? more

Topics: Matrix metalloproteinase (51%)

5,568 Citations

Journal ArticleDOI: 10.1038/NRC1187
Gregg L. Semenza1Institutions (1)
Abstract: Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion. Intratumoral hypoxia and genetic alterations can lead to HIF-1alpha overexpression, which has been associated with increased patient mortality in several cancer types. In preclinical studies, inhibition of HIF-1 activity has marked effects on tumour growth. Efforts are underway to identify inhibitors of HIF-1 and to test their efficacy as anticancer therapeutics. more

Topics: HIF1A (60%), Hypoxia-inducible factors (56%), Angiogenesis (52%) more

5,551 Citations

No. of papers from the Journal in previous years

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Journal's top 5 most impactful authors

Nicola McCarthy

338 papers, 953 citations

Sarah Seton-Rogers

297 papers, 803 citations

Gemma K. Alderton

210 papers, 532 citations

Kristine Novak

109 papers, 124 citations

Ezzie Hutchinson

93 papers, 74 citations

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