A
Alicia Boto
Researcher at Spanish National Research Council
Publications - 77
Citations - 1180
Alicia Boto is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Amino acid & Decarboxylation. The author has an hindex of 20, co-authored 70 publications receiving 978 citations. Previous affiliations of Alicia Boto include University of Nottingham.
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Simplification of antitumoral phenanthroindolizidine alkaloids: short synthesis of cytotoxic indolizidinone and pyrrolidine analogs.
TL;DR: Hydroxylated seco-analogs of cytotoxic phenanthroindolizidine alkaloids were prepared in good yields from inexpensive 4-hydroxyproline derivatives, using a sequential oxidative radical scission-oxidation for the direct conversion of the proline derivative into a 2-aryl-oxoethyl pyrrolidine with a variety of aryl and heteroaryl groups.
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Synthesis of acyclic nucleosides and other C-1 substituted alditols from carbohydrates using a tandem alkoxyl radical β-fragmentation–nucleophilic addition
TL;DR: In this article, the oxidative β-fragmentation of alkoxyl radicals generated from easily available carbohydrates is an efficient methodology to obtain acyclic nucleosides and other C-1 substituted alditols.
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Site-selective modification of peptide backbones
Alicia Boto,Concepción C. González,Dácil Hernández,Ivan Romero-Estudillo,Ivan Romero-Estudillo,Carlos J. Saavedra,Carlos J. Saavedra +6 more
TL;DR: In this article, a review of site-selective modification of peptide backbones is presented, from the use of customizable units to residue-directed introduction of substituents.
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Metal-Free, Site-Selective Peptide Modification by Conversion of “Customizable” Units into β-Substituted Dehydroamino Acids
TL;DR: The authors' site-selective modification of serine or threonine units in peptides allows the generation of β-substituted dehydroamino acids, which increase peptide resistance to hydrolysis and may improve their biological properties.
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Synthesis of Diketopiperazine Scaffolds with Tailored N‐ and α‐Chains by Selective Modification of Customizable Units
TL;DR: In this paper, the APOGEO (Cooperation Program INTERREG•MAC 2014-2020, with European Funds for Regional Development•FEDER) and European Social Funds (ESF) projects SAF•2013−48399•R, Plan Estatal I+D+RETOS (MINECO•MCIU) and CONACYT 2015−01•807 (CONACYT‐Mexico) were used.