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Alifya Oultache
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 6
Citations - 1610
Alifya Oultache is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Mutation frequency & Deep sequencing. The author has an hindex of 5, co-authored 6 publications receiving 1177 citations.
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Journal ArticleDOI
Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology
Donavan T. Cheng,Talia Mitchell,Ahmet Zehir,Ronak Shah,Ryma Benayed,Aijazuddin Syed,Raghu Chandramohan,Zhen Yu Liu,Helen Won,Sasinya N. Scott,A. Rose Brannon,Catherine O'Reilly,Justyna Sadowska,Jacklyn Casanova,Angela Yannes,Jaclyn F. Hechtman,Jinjuan Yao,Wei Song,Dara S. Ross,Alifya Oultache,Snjezana Dogan,Laetitia Borsu,Meera Hameed,Khedoudja Nafa,Maria E. Arcila,Marc Ladanyi,Michael F. Berger +26 more
TL;DR: Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) is developed, a hybridization capture-based next-generation sequencing assay for targeted deep sequencing of all exons and selected introns of 341 key cancer genes in formalin-fixed, paraffin-embedded tumors.
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Additional Primary Malignancies in Patients with Gastrointestinal Stromal Tumor (GIST): A Clinicopathologic Study of 260 Patients with Molecular Analysis and Review of the Literature
Jaclyn F. Hechtman,Ronald P. DeMatteo,Khedoudja Nafa,Ping Chi,Maria E. Arcila,Snjezana Dogan,Alifya Oultache,Wen Chen,Meera Hameed +8 more
TL;DR: This is the first report to describe a relationship between additional primary malignancy and both mutation and mitotic rate of GIST, and caution in the clinical management of Gist patients with additional lesions is warranted.
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Detection of Mutations in Myeloid Malignancies through Paired-Sample Analysis of Microdroplet-PCR Deep Sequencing Data
Donavan T. Cheng,Janice Cheng,Talia Mitchell,Aijazuddin Syed,Ahmet Zehir,Nana Mensah,Alifya Oultache,Khedoudja Nafa,Ross L. Levine,Maria E. Arcila,Michael F. Berger,Cyrus V. Hedvat +11 more
TL;DR: A paired-sample analysis pipeline capable of robust identification of mutations from microdroplet-PCR sequencing data with high sensitivity and specificity is developed.
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Novel oncogene and tumor suppressor mutations in KIT and PDGFRA wild type gastrointestinal stromal tumors revealed by next generation sequencing.
Jaclyn F. Hechtman,Ahmet Zehir,Talia Mitchell,Laetitia Borsu,Samuel Singer,William D. Tap,Alifya Oultache,Marc Ladanyi,Khedoudja Nafa +8 more
TL;DR: KRAS mutations occur in rare GISTs with wild type KIT and PDGFRA, and these tumors may display immunohistochemical positivity for K IT and primary resistance to tyrosine kinase inhibitors.
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GNAS Mutations in Fibrous Dysplasia: A Comparative Study of Standard Sequencing and Locked Nucleic Acid PCR Sequencing on Decalcified and Nondecalcified Formalin-fixed Paraffin-embedded Tissues.
George Jour,Alifya Oultache,Justyna Sadowska,Talia Mitchell,John H. Healey,Khedoudja Nafa,Meera Hameed +6 more
TL;DR: There was a significant difference in the sensitivity of the assay between decalcification and nondecalcified FDs (31% vs. 70%, P=0.002), and LNA-PCR has no added value in enhancing detection sensitivity for GNAS mutations in FD.